A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder associated with underlying benign or malignant neoplasia. Its signs and symptoms may be the first presentation of a concealed malignancy. Due to late diagnosis, prognosis of PNP is not good, so early diagnosis and treatment is of paramoun...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2021-10-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://nepjol.info/index.php/NJDVL/article/view/38680 |
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| _version_ | 1849226817450278912 |
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| author | Harihar Adhikari Deeptara Pathak Thapa Priya Bhusal |
| author_facet | Harihar Adhikari Deeptara Pathak Thapa Priya Bhusal |
| author_sort | Harihar Adhikari |
| collection | DOAJ |
| description |
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder associated with underlying benign or malignant neoplasia. Its signs and symptoms may be the first presentation of a concealed malignancy. Due to late diagnosis, prognosis of PNP is not good, so early diagnosis and treatment is of paramount importance. We present a case of 22 years old female who presented to our out patient department (OPD) with history of recurrent, severe, recalcitrant, painful oral ulcers; lichenoid lesions over the hands and feet and widespread blistering and erosions involving the soles. Histopathological examination was consistent with paraneoplastic pemphigus and showed features of lichenoid dermatitis. CT scan revealed retroperitoneal mass suggestive of Castleman disease. The patient was referred to surgical team for further management.
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| format | Article |
| id | doaj-art-c052104f640949258c1799f998b0e406 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-c052104f640949258c1799f998b0e4062025-08-24T10:05:56ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2021-10-01192A Sinister Disease Hides Behind Recalcitrant Mucocutaneous DisorderHarihar Adhikari0Deeptara Pathak Thapa1Priya Bhusal2Nepal medical college and teaching hospitalNepal medical college and teaching hospitalLet me in skin hospital Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder associated with underlying benign or malignant neoplasia. Its signs and symptoms may be the first presentation of a concealed malignancy. Due to late diagnosis, prognosis of PNP is not good, so early diagnosis and treatment is of paramount importance. We present a case of 22 years old female who presented to our out patient department (OPD) with history of recurrent, severe, recalcitrant, painful oral ulcers; lichenoid lesions over the hands and feet and widespread blistering and erosions involving the soles. Histopathological examination was consistent with paraneoplastic pemphigus and showed features of lichenoid dermatitis. CT scan revealed retroperitoneal mass suggestive of Castleman disease. The patient was referred to surgical team for further management. https://nepjol.info/index.php/NJDVL/article/view/38680Castleman diseaseLichenoid dermatitisParaneoplastic pemphigus |
| spellingShingle | Harihar Adhikari Deeptara Pathak Thapa Priya Bhusal A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder Nepal Journal of Dermatology, Venereology & Leprology Castleman disease Lichenoid dermatitis Paraneoplastic pemphigus |
| title | A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder |
| title_full | A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder |
| title_fullStr | A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder |
| title_full_unstemmed | A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder |
| title_short | A Sinister Disease Hides Behind Recalcitrant Mucocutaneous Disorder |
| title_sort | sinister disease hides behind recalcitrant mucocutaneous disorder |
| topic | Castleman disease Lichenoid dermatitis Paraneoplastic pemphigus |
| url | https://nepjol.info/index.php/NJDVL/article/view/38680 |
| work_keys_str_mv | AT hariharadhikari asinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder AT deeptarapathakthapa asinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder AT priyabhusal asinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder AT hariharadhikari sinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder AT deeptarapathakthapa sinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder AT priyabhusal sinisterdiseasehidesbehindrecalcitrantmucocutaneousdisorder |