AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level

AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level

IntroductionUnresolved hepatitis B virus (HBV) infection leads to a progressive state of HBV-specific immune dysfunctionality that characterizes chronic infection. The immune-competent adeno associated virus (AAV)-HBV mouse model is commonly used preclinically, though a comprehensive characterizatio...

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Main Authors: Nádia Conceição-Neto, Wim Pierson, Qinglin Han, Zhiyuan Yao, Qun Wu, Koen Dockx, Liese Aerts, Dries De Maeyer, Matthias Beyens, Koen Van den Berge, Chris Li, George Kukolj, Ren Zhu, Vinod Krishna, Ondřej Podlaha, Isabel Nájera, Ellen Van Gulck
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
hepatitis B virus
single-cell transcriptome
AAV-HBV-infected mouse model
T cell exhaustion
chronic HBV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1421712/full
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