Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges

The integration of nanotechnology into biosensor design has propelled significant advancements, transforming them into essential tools for precise and rapid detection in diverse fields. This comprehensive review highlights the latest innovations in nanotechnology-enhanced biosensors, emphasizing the...

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Main Authors: Mohamed Hemdan, Khaled Abuelhaded, Abanoub A.S. Shaker, Mohamed M. Ashour, Moustafa M. Abdelaziz, Mohammed I. Dahab, Yara A. Nassar, Amir M.M. Sarguos, Pola S. Zakaria, Haidy A. Fahmy, Sherif S. Abdel Mageed, Mariam O.A. Hamed, Mahmoud F. Mubarak, Mostafa A. Taher, Najla F. Gumaah, Ahmed H. Ragab
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Sensing and Bio-Sensing Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S2214180425000492
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author Mohamed Hemdan
Khaled Abuelhaded
Abanoub A.S. Shaker
Mohamed M. Ashour
Moustafa M. Abdelaziz
Mohammed I. Dahab
Yara A. Nassar
Amir M.M. Sarguos
Pola S. Zakaria
Haidy A. Fahmy
Sherif S. Abdel Mageed
Mariam O.A. Hamed
Mahmoud F. Mubarak
Mostafa A. Taher
Najla F. Gumaah
Ahmed H. Ragab
author_facet Mohamed Hemdan
Khaled Abuelhaded
Abanoub A.S. Shaker
Mohamed M. Ashour
Moustafa M. Abdelaziz
Mohammed I. Dahab
Yara A. Nassar
Amir M.M. Sarguos
Pola S. Zakaria
Haidy A. Fahmy
Sherif S. Abdel Mageed
Mariam O.A. Hamed
Mahmoud F. Mubarak
Mostafa A. Taher
Najla F. Gumaah
Ahmed H. Ragab
author_sort Mohamed Hemdan
collection DOAJ
description The integration of nanotechnology into biosensor design has propelled significant advancements, transforming them into essential tools for precise and rapid detection in diverse fields. This comprehensive review highlights the latest innovations in nanotechnology-enhanced biosensors, emphasizing their role in healthcare, environmental monitoring, and food safety. It explores how advancements in signal transduction, detection limits, and surface functionalisation have enabled early disease diagnosis through biomarker detection, precise therapeutic drug monitoring, and real-time health assessments. In environmental applications, these biosensors offer unparalleled accuracy in detecting pollutants and pathogens, addressing critical challenges in water and air quality monitoring. In food safety, they ensure rapid identification of contaminants, including toxins, pesticide residues, and pathogens, supporting compliance with stringent safety standards. The review also examines challenges such as scalability and regulatory constraints, while discussing the transformative potential of emerging technologies like artificial intelligence, Internet of Things, and 3D printing. This comprehensive analysis provides valuable insights into the evolving applications and future potential of nanotechnology-driven biosensors.
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series Sensing and Bio-Sensing Research
spelling doaj-art-c044962cdae44f4f95069611d4e0b89e2025-08-20T02:07:40ZengElsevierSensing and Bio-Sensing Research2214-18042025-06-014810078310.1016/j.sbsr.2025.100783Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challengesMohamed Hemdan0Khaled Abuelhaded1Abanoub A.S. Shaker2Mohamed M. Ashour3Moustafa M. Abdelaziz4Mohammed I. Dahab5Yara A. Nassar6Amir M.M. Sarguos7Pola S. Zakaria8Haidy A. Fahmy9Sherif S. Abdel Mageed10Mariam O.A. Hamed11Mahmoud F. Mubarak12Mostafa A. Taher13Najla F. Gumaah14Ahmed H. Ragab15School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Corresponding author.School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptBiotechnology and Its Application Program, Department of Botany, Faculty of Science, Mansoura University, Mansoura 35516, EgyptMedical Biotechnologies, Molecular Medicine Department, Faculty of Medicine and Surgery, university of Padova, 35122 Padua, ItalyBiotechnology Program, Faculty of Science, Ain Shams University, Cairo 11566, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, EgyptPetroleum Application Department, Egyptian Petroleum Research Institute (EPRI), Cairo 11727, Egypt; Core lab center, Egyptian Petroleum Research Institute (EPRI), 1 Ahmed El Zomor st., Nasr City, Cairo 11727, EgyptBiology Department, Faculty of Science and Arts, King Khalid University, Mohail Assir 61321, Saudi ArabiaChemistry Department, Faculty of Science, Northern Border University, Saudi ArabiaChemistry Department, College of Science, King Khalid University, 61413 Abha, Saudi ArabiaThe integration of nanotechnology into biosensor design has propelled significant advancements, transforming them into essential tools for precise and rapid detection in diverse fields. This comprehensive review highlights the latest innovations in nanotechnology-enhanced biosensors, emphasizing their role in healthcare, environmental monitoring, and food safety. It explores how advancements in signal transduction, detection limits, and surface functionalisation have enabled early disease diagnosis through biomarker detection, precise therapeutic drug monitoring, and real-time health assessments. In environmental applications, these biosensors offer unparalleled accuracy in detecting pollutants and pathogens, addressing critical challenges in water and air quality monitoring. In food safety, they ensure rapid identification of contaminants, including toxins, pesticide residues, and pathogens, supporting compliance with stringent safety standards. The review also examines challenges such as scalability and regulatory constraints, while discussing the transformative potential of emerging technologies like artificial intelligence, Internet of Things, and 3D printing. This comprehensive analysis provides valuable insights into the evolving applications and future potential of nanotechnology-driven biosensors.http://www.sciencedirect.com/science/article/pii/S2214180425000492BiosensorsNanomaterialsHealthcare applicationsEnvironmental monitoring
spellingShingle Mohamed Hemdan
Khaled Abuelhaded
Abanoub A.S. Shaker
Mohamed M. Ashour
Moustafa M. Abdelaziz
Mohammed I. Dahab
Yara A. Nassar
Amir M.M. Sarguos
Pola S. Zakaria
Haidy A. Fahmy
Sherif S. Abdel Mageed
Mariam O.A. Hamed
Mahmoud F. Mubarak
Mostafa A. Taher
Najla F. Gumaah
Ahmed H. Ragab
Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
Sensing and Bio-Sensing Research
Biosensors
Nanomaterials
Healthcare applications
Environmental monitoring
title Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
title_full Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
title_fullStr Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
title_full_unstemmed Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
title_short Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges
title_sort recent advances in nano enhanced biosensors innovations in design applications in healthcare environmental monitoring and food safety and emerging research challenges
topic Biosensors
Nanomaterials
Healthcare applications
Environmental monitoring
url http://www.sciencedirect.com/science/article/pii/S2214180425000492
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