Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond

Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond

Abstract Background Integration of immune checkpoint inhibitors (ICIs) with non-immune therapies relies on identifying combinatorial biomarkers, which are essential for patient stratification and personalized treatment. Methods We analyzed genomic and transcriptomic data from pretreatment tumor samp...

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Bibliographic Details
Main Authors: Jiaxin Wen, Yanfeng Wang, Song Wang, Yuxin Liang, Xiaozhen Hu, Qiuxiang Ou, Hua Bao, Kuo Zhao, Youyu Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Immune checkpoint inhibitor
Clinical response
Biomarker
DNAH
Gene expression
Online Access:https://doi.org/10.1186/s12967-025-06467-6
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