New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma

New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma

Primary central nervous system lymphoma (PCNSL) is non-Hodgkin’s lymphoma (NHL) confined to the central nervous system. Most of the patients eventually develop relapsed/refractory (R/R) PCNSL, and the overall prognosis for PCNSL remains dismal. Recently, gene sequencing, transcriptome sequencing, an...

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Bibliographic Details
Main Authors: Chuanwei Yang, Xiaohui Ren, Yong Cui, Haihui Jiang, Ming Li, Kefu Yu, Shaoping Shen, Mingxiao Li, Xiaokang Zhang, Xuzhe Zhao, Qinghui Zhu, Xingyao Bu, Song Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
primary central nervous system lymphoma
high-dose methotrexate
targeted therapy
immunotherapy
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1438001/full
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