Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform

Grass-clover is one of the main biomass crops in northern Europe relevant for green biorefining to produce protein feed ingredients. The present study investigated the unique combination of a green biorefinery platform and supercritical carbon dioxide (scCO2) to extract lipids and biocompounds besid...

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Main Authors: Damian E.L. Fetzer, Jose A.P. Coelho, Morten Ambye-Jensen
Format: Article
Language:English
Published: Elsevier 2025-11-01
Series:Journal of CO2 Utilization
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Online Access:http://www.sciencedirect.com/science/article/pii/S2212982025001829
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author Damian E.L. Fetzer
Jose A.P. Coelho
Morten Ambye-Jensen
author_facet Damian E.L. Fetzer
Jose A.P. Coelho
Morten Ambye-Jensen
author_sort Damian E.L. Fetzer
collection DOAJ
description Grass-clover is one of the main biomass crops in northern Europe relevant for green biorefining to produce protein feed ingredients. The present study investigated the unique combination of a green biorefinery platform and supercritical carbon dioxide (scCO2) to extract lipids and biocompounds besides improving the downstream process from grass-clover leaf protein concentrate (LPC) and grass-clover fibrous press cake (FPC). Grass-clover was harvested and processed on a green biorefinery demonstration platform to yield both LPC and FPC. Then, supercritical CO2 was used by a design of experiments (DoE) method utilizing two factors (temperature and pressure) for process and optimization to obtain the extracts from LPC. Oil extraction yields from 5.41 % to 8.20 % based on dry matter was obtained. The best experimental conditions of 357.1 K and 50 MPa, were obtained for LPC oil extraction and were applied to extract oil from FPC, achieving 2.5 % oil extract. The scCO2 extracts contained 1,4-Eicosadiene, Neophytadiene, and Phytol as the main compounds, including lipid rich in omega-3 polyunsaturated fatty acids, which also contains phenolic and flavonoid compounds in the extracts. Protein concentration increases on LPC and PFC after defatting extractions. In conclusion, the integration in a green biorefining process with scCO2 showed extracts rich in lipids that are generally used in different food/pharmaceutical applications and, at the same time, served as a downstream process, increasing the protein content in the LPC. ScCO2 of FPC generated lignocellulosic rich in lipid-free fibers that can be used in further cascade valorization to produce biomaterials and chemicals.
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spelling doaj-art-c02b098d4ea74570aeb00cef59a838112025-08-23T04:48:20ZengElsevierJournal of CO2 Utilization2212-98392025-11-0110110319810.1016/j.jcou.2025.103198Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platformDamian E.L. Fetzer0Jose A.P. Coelho1Morten Ambye-Jensen2Department of Biological and Chemical Engineering, Aarhus University, Hangøvej 2, Aarhus 8200, Denmark; Aarhus University Centre for Circular Bioeconomy, Tjele 8830, DenmarkInstituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Lisboa 1959-007, Portugal; Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, PortugalDepartment of Biological and Chemical Engineering, Aarhus University, Hangøvej 2, Aarhus 8200, Denmark; Aarhus University Centre for Circular Bioeconomy, Tjele 8830, Denmark; Corresponding author at: Department of Biological and Chemical Engineering, Aarhus University, Hangøvej 2, Aarhus 8200, Denmark.Grass-clover is one of the main biomass crops in northern Europe relevant for green biorefining to produce protein feed ingredients. The present study investigated the unique combination of a green biorefinery platform and supercritical carbon dioxide (scCO2) to extract lipids and biocompounds besides improving the downstream process from grass-clover leaf protein concentrate (LPC) and grass-clover fibrous press cake (FPC). Grass-clover was harvested and processed on a green biorefinery demonstration platform to yield both LPC and FPC. Then, supercritical CO2 was used by a design of experiments (DoE) method utilizing two factors (temperature and pressure) for process and optimization to obtain the extracts from LPC. Oil extraction yields from 5.41 % to 8.20 % based on dry matter was obtained. The best experimental conditions of 357.1 K and 50 MPa, were obtained for LPC oil extraction and were applied to extract oil from FPC, achieving 2.5 % oil extract. The scCO2 extracts contained 1,4-Eicosadiene, Neophytadiene, and Phytol as the main compounds, including lipid rich in omega-3 polyunsaturated fatty acids, which also contains phenolic and flavonoid compounds in the extracts. Protein concentration increases on LPC and PFC after defatting extractions. In conclusion, the integration in a green biorefining process with scCO2 showed extracts rich in lipids that are generally used in different food/pharmaceutical applications and, at the same time, served as a downstream process, increasing the protein content in the LPC. ScCO2 of FPC generated lignocellulosic rich in lipid-free fibers that can be used in further cascade valorization to produce biomaterials and chemicals.http://www.sciencedirect.com/science/article/pii/S2212982025001829LipidsSupercritical CO2Grass-cloverPress-cake-fiberLeaf protein concentrateGreen biorefinery
spellingShingle Damian E.L. Fetzer
Jose A.P. Coelho
Morten Ambye-Jensen
Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
Journal of CO2 Utilization
Lipids
Supercritical CO2
Grass-clover
Press-cake-fiber
Leaf protein concentrate
Green biorefinery
title Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
title_full Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
title_fullStr Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
title_full_unstemmed Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
title_short Extraction of lipids with supercritical CO2 and downstream processing from grass-clover products from a green biorefinery demonstration platform
title_sort extraction of lipids with supercritical co2 and downstream processing from grass clover products from a green biorefinery demonstration platform
topic Lipids
Supercritical CO2
Grass-clover
Press-cake-fiber
Leaf protein concentrate
Green biorefinery
url http://www.sciencedirect.com/science/article/pii/S2212982025001829
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AT joseapcoelho extractionoflipidswithsupercriticalco2anddownstreamprocessingfromgrasscloverproductsfromagreenbiorefinerydemonstrationplatform
AT mortenambyejensen extractionoflipidswithsupercriticalco2anddownstreamprocessingfromgrasscloverproductsfromagreenbiorefinerydemonstrationplatform