Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study
PurposeThis study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).MethodsWe analyzed the cor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1470747/full |
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| author | Chenyu Fan Hanfei Li Hanfei Li Ke Chen Ke Chen Guohui Yang Hongyu Xie Haozheng Li Yi Wu Meng Li Meng Li Meng Li |
| author_facet | Chenyu Fan Hanfei Li Hanfei Li Ke Chen Ke Chen Guohui Yang Hongyu Xie Haozheng Li Yi Wu Meng Li Meng Li Meng Li |
| author_sort | Chenyu Fan |
| collection | DOAJ |
| description | PurposeThis study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).MethodsWe analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). The Stroop task is divided into early stage (0–15 s) and late stage (15–30 s). We also measured participants’ behavior during the Stroop task, analyzed variations in cortical activation intensity at different experiment stages, and performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, Stroop performance, and oxygenation levels.ResultsOur analysis revealed that individuals with MCI and HC demonstrated elevated cortical activation in the dPFC, VLPFC, and PL areas while performing the Stroop task (q < 0.05, FDR-corrected). The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. The MCI group showed compensatory activation in the VLPFC, and PL regions compared to the HC group during the late stage of the Stroop task (q < 0.05, FDR-corrected). Correlational analysis revealed a negative association between MoCA scores and oxygenation levels in the dPFC, VLPFC, and PL regions during the late stage of the Stroop task (p < 0.05). However, no correlation was found with behavioral performance.ConclusionMild cognitive impairment patients demonstrated effective compensation for their cognitive impairments at a partial behavioral level by engaging compensatory activation in the prefrontal, and parietal regions while performing the Stroop task. |
| format | Article |
| id | doaj-art-c029387a27334965a6cc8d5147bb5a1d |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-c029387a27334965a6cc8d5147bb5a1d2025-02-07T06:49:53ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.14707471470747Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy studyChenyu Fan0Hanfei Li1Hanfei Li2Ke Chen3Ke Chen4Guohui Yang5Hongyu Xie6Haozheng Li7Yi Wu8Meng Li9Meng Li10Meng Li11Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Transducer Technology, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Transducer Technology, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Transducer Technology, University of Chinese Academy of Sciences, Beijing, ChinaINSIDE Institute for Biological and Artificial Intelligence, Shanghai, ChinaPurposeThis study investigated the disparities in brain activation patterns during the Stroop task among individuals with mild cognitive impairment (MCI) and those without any cognitive impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS).MethodsWe analyzed the cortical activation patterns of 73 patients with MCI and 63 HC individuals as they completed the Stroop task, employing fNIRS. The regions of interest (ROIs) included the dorsal prefrontal cortex (dPFC), ventrolateral prefrontal cortex (VLPFC), and parietal lobe (PL). The Stroop task is divided into early stage (0–15 s) and late stage (15–30 s). We also measured participants’ behavior during the Stroop task, analyzed variations in cortical activation intensity at different experiment stages, and performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, Stroop performance, and oxygenation levels.ResultsOur analysis revealed that individuals with MCI and HC demonstrated elevated cortical activation in the dPFC, VLPFC, and PL areas while performing the Stroop task (q < 0.05, FDR-corrected). The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. The MCI group showed compensatory activation in the VLPFC, and PL regions compared to the HC group during the late stage of the Stroop task (q < 0.05, FDR-corrected). Correlational analysis revealed a negative association between MoCA scores and oxygenation levels in the dPFC, VLPFC, and PL regions during the late stage of the Stroop task (p < 0.05). However, no correlation was found with behavioral performance.ConclusionMild cognitive impairment patients demonstrated effective compensation for their cognitive impairments at a partial behavioral level by engaging compensatory activation in the prefrontal, and parietal regions while performing the Stroop task.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1470747/fullmild cognitive impairmentfNIRSexecutive functionStroop taskcortical compensatory activation |
| spellingShingle | Chenyu Fan Hanfei Li Hanfei Li Ke Chen Ke Chen Guohui Yang Hongyu Xie Haozheng Li Yi Wu Meng Li Meng Li Meng Li Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study Frontiers in Aging Neuroscience mild cognitive impairment fNIRS executive function Stroop task cortical compensatory activation |
| title | Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study |
| title_full | Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study |
| title_fullStr | Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study |
| title_full_unstemmed | Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study |
| title_short | Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study |
| title_sort | brain compensatory activation during stroop task in patients with mild cognitive impairment a functional near infrared spectroscopy study |
| topic | mild cognitive impairment fNIRS executive function Stroop task cortical compensatory activation |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1470747/full |
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