Population-Based Placental Weight Ratio Distributions
The placental weight ratio (PWR) is a health indicator that reflects the balance between fetal and placental growth. The PWR is defined as the placental weight divided by the birth weight, and it changes across gestation. Its ranges are not well established. We aimed to establish PWR distributions b...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/291846 |
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| author | Erin M. Macdonald John J. Koval Renato Natale Timothy Regnault M. Karen Campbell |
| author_facet | Erin M. Macdonald John J. Koval Renato Natale Timothy Regnault M. Karen Campbell |
| author_sort | Erin M. Macdonald |
| collection | DOAJ |
| description | The placental weight ratio (PWR) is a health indicator that reflects the balance between fetal and placental growth. The PWR is defined as the placental weight divided by the birth weight, and it changes across gestation. Its ranges are not well established. We aimed to establish PWR distributions by gestational age and to investigate whether the PWR distributions vary by fetal growth adequacy, small, average, and large for gestational age (SGA, AGA, and LGA). The data came from a hospital based retrospective cohort, using all births at two London, Ontario hospitals in the past 10 years. All women who delivered a live singleton infant between 22 and 42 weeks of gestation were included (n=41441). Nonparametric quantile regression was used to fit the curves. The results demonstrate decreasing PWR and dispersion, with increasing gestational age. A higher proportion of SGA infants have extreme PWRs than AGA and LGA, especially at lower gestational ages. On average, SGA infants had higher PWRs than AGA and LGA infants. The overall curves offer population standards for use in research studies. The curves stratified by fetal growth adequacy are the first of their kind, and they demonstrate that PWR differs for SGA and LGA infants. |
| format | Article |
| id | doaj-art-c0282be5720445ad857e3194bb768efc |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Pediatrics |
| spelling | doaj-art-c0282be5720445ad857e3194bb768efc2025-02-03T06:42:20ZengWileyInternational Journal of Pediatrics1687-97401687-97592014-01-01201410.1155/2014/291846291846Population-Based Placental Weight Ratio DistributionsErin M. Macdonald0John J. Koval1Renato Natale2Timothy Regnault3M. Karen Campbell4Department of Epidemiology and Biostatistics, The University of Western Ontario, London, ON, N6A 5C1, CanadaDepartment of Epidemiology and Biostatistics, The University of Western Ontario, London, ON, N6A 5C1, CanadaDepartment of Obstetrics and Gynecology, The University of Western Ontario, London, ON, N6A 5C1, CanadaDepartment of Obstetrics and Gynecology, The University of Western Ontario, London, ON, N6A 5C1, CanadaDepartment of Epidemiology and Biostatistics, The University of Western Ontario, London, ON, N6A 5C1, CanadaThe placental weight ratio (PWR) is a health indicator that reflects the balance between fetal and placental growth. The PWR is defined as the placental weight divided by the birth weight, and it changes across gestation. Its ranges are not well established. We aimed to establish PWR distributions by gestational age and to investigate whether the PWR distributions vary by fetal growth adequacy, small, average, and large for gestational age (SGA, AGA, and LGA). The data came from a hospital based retrospective cohort, using all births at two London, Ontario hospitals in the past 10 years. All women who delivered a live singleton infant between 22 and 42 weeks of gestation were included (n=41441). Nonparametric quantile regression was used to fit the curves. The results demonstrate decreasing PWR and dispersion, with increasing gestational age. A higher proportion of SGA infants have extreme PWRs than AGA and LGA, especially at lower gestational ages. On average, SGA infants had higher PWRs than AGA and LGA infants. The overall curves offer population standards for use in research studies. The curves stratified by fetal growth adequacy are the first of their kind, and they demonstrate that PWR differs for SGA and LGA infants.http://dx.doi.org/10.1155/2014/291846 |
| spellingShingle | Erin M. Macdonald John J. Koval Renato Natale Timothy Regnault M. Karen Campbell Population-Based Placental Weight Ratio Distributions International Journal of Pediatrics |
| title | Population-Based Placental Weight Ratio Distributions |
| title_full | Population-Based Placental Weight Ratio Distributions |
| title_fullStr | Population-Based Placental Weight Ratio Distributions |
| title_full_unstemmed | Population-Based Placental Weight Ratio Distributions |
| title_short | Population-Based Placental Weight Ratio Distributions |
| title_sort | population based placental weight ratio distributions |
| url | http://dx.doi.org/10.1155/2014/291846 |
| work_keys_str_mv | AT erinmmacdonald populationbasedplacentalweightratiodistributions AT johnjkoval populationbasedplacentalweightratiodistributions AT renatonatale populationbasedplacentalweightratiodistributions AT timothyregnault populationbasedplacentalweightratiodistributions AT mkarencampbell populationbasedplacentalweightratiodistributions |