Long-term efficacy of therapeutic drug monitoring-guided optimization of ustekinumab maintenance therapy for Crohn’s disease patients

Long-term efficacy of therapeutic drug monitoring-guided optimization of ustekinumab maintenance therapy for Crohn’s disease patients

Abstract Long-term remission in Crohn’s disease (CD) remains challenging. While ustekinumab effectively induces remission, strategies to enhance its maintenance efficacy are urgently needed. This study evaluated therapeutic drug monitoring (TDM)-guided ustekinumab optimization for sustained CD manag...

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Main Authors: Haixia Ren, Juan Su, Anning Yin, Xinsheng Gao, Wei Wang, Jiao Li, Jian Kang, Jing Wang, Qian Zhou, Jing An, Zhishun Tang, Xinxin Wang, Huipeng Wan, Wei Chen, Pengbo Wu, Ping An
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09802-5
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