Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder
BackgroundMajor depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1413608/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159451236990976 |
|---|---|
| author | Dandan Geng Dandan Geng Wenxin Wang Ning Du Ning Du Lisa Cynthia Niwenahisemo Lisa Cynthia Niwenahisemo Heyan Xu Heyan Xu Yuna Wang Yuna Wang Li Kuang |
| author_facet | Dandan Geng Dandan Geng Wenxin Wang Ning Du Ning Du Lisa Cynthia Niwenahisemo Lisa Cynthia Niwenahisemo Heyan Xu Heyan Xu Yuna Wang Yuna Wang Li Kuang |
| author_sort | Dandan Geng |
| collection | DOAJ |
| description | BackgroundMajor depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related to the progression of MDD. The aim of this study was to investigate the correlation between the neutrophil-to-platelet ratio (NPR) during the acute phase and the effectiveness of ECT treatment.MethodsA total of 138 adolescent MDD patients who received ECT were included in the study. Neutrophil and platelet levels were obtained upon admission. At the same time, treatment response was the primary outcome measure, defined as a reduction of ≥ 50% in the HAMD-17 score from baseline to treatment endpoint, and the secondary outcome measure was remission of depression, defined as a HAMD-17 score ≤ 7.ResultsAfter receiving ECT, 103(74.6%) of all patients responded to treatment and 72(52.2%) achieved remission. Non-responders/non-remitters to ECT tended to have higher levels of NPR at baseline compared to ECT responders/remitters [Non-responder: 3.4 (2.5-4.8) vs 2.7 (2.2-3.5), P = 0.002; Non-remitter: 0.014 (0.011-0.017) vs 0.011 (0.008-0.015), P = 0.03]. In multiple logistic regression, high NPR (≥ 0.014) remained independently associated with ECT non-response/non-remission after adjusting for confounding factors [Non-responder: OR = 4.911, 95% CI (2.052 - 11.754), P < 0.001; Non-remitter: OR = 2.704, 95% CI (1.262 - 5.796), P = 0.011].ConclusionHigh NPR correlates with poor ECT efficacy in adolescents with MDD, particularly among female and overweight patients. |
| format | Article |
| id | doaj-art-c0210c2ce5444ad8bc818c84697a5d4a |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-c0210c2ce5444ad8bc818c84697a5d4a2025-08-20T02:23:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-11-011510.3389/fpsyt.2024.14136081413608Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorderDandan Geng0Dandan Geng1Wenxin Wang2Ning Du3Ning Du4Lisa Cynthia Niwenahisemo5Lisa Cynthia Niwenahisemo6Heyan Xu7Heyan Xu8Yuna Wang9Yuna Wang10Li Kuang11Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaThe First Clinical College of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundMajor depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related to the progression of MDD. The aim of this study was to investigate the correlation between the neutrophil-to-platelet ratio (NPR) during the acute phase and the effectiveness of ECT treatment.MethodsA total of 138 adolescent MDD patients who received ECT were included in the study. Neutrophil and platelet levels were obtained upon admission. At the same time, treatment response was the primary outcome measure, defined as a reduction of ≥ 50% in the HAMD-17 score from baseline to treatment endpoint, and the secondary outcome measure was remission of depression, defined as a HAMD-17 score ≤ 7.ResultsAfter receiving ECT, 103(74.6%) of all patients responded to treatment and 72(52.2%) achieved remission. Non-responders/non-remitters to ECT tended to have higher levels of NPR at baseline compared to ECT responders/remitters [Non-responder: 3.4 (2.5-4.8) vs 2.7 (2.2-3.5), P = 0.002; Non-remitter: 0.014 (0.011-0.017) vs 0.011 (0.008-0.015), P = 0.03]. In multiple logistic regression, high NPR (≥ 0.014) remained independently associated with ECT non-response/non-remission after adjusting for confounding factors [Non-responder: OR = 4.911, 95% CI (2.052 - 11.754), P < 0.001; Non-remitter: OR = 2.704, 95% CI (1.262 - 5.796), P = 0.011].ConclusionHigh NPR correlates with poor ECT efficacy in adolescents with MDD, particularly among female and overweight patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1413608/fullmajor depressive disorderelectroconvulsive therapyadolescentsneutrophil-to-platelet ratioresponse |
| spellingShingle | Dandan Geng Dandan Geng Wenxin Wang Ning Du Ning Du Lisa Cynthia Niwenahisemo Lisa Cynthia Niwenahisemo Heyan Xu Heyan Xu Yuna Wang Yuna Wang Li Kuang Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder Frontiers in Psychiatry major depressive disorder electroconvulsive therapy adolescents neutrophil-to-platelet ratio response |
| title | Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| title_full | Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| title_fullStr | Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| title_full_unstemmed | Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| title_short | Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| title_sort | association of the neutrophil to platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder |
| topic | major depressive disorder electroconvulsive therapy adolescents neutrophil-to-platelet ratio response |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1413608/full |
| work_keys_str_mv | AT dandangeng associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT dandangeng associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT wenxinwang associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT ningdu associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT ningdu associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT lisacynthianiwenahisemo associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT lisacynthianiwenahisemo associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT heyanxu associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT heyanxu associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT yunawang associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT yunawang associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder AT likuang associationoftheneutrophiltoplateletratiowithresponsetoelectroconvulsivetherapyinadolescentswithmajordepressivedisorder |