Calcification of the elastic component: the impact on the cardiovascular system
In the cardiovascular system, elastic fibres exert a fundamental role providing the long-range elasticity required for physiological functions. Elastic fibres are complex in composition and structure containing, in addition to elastin, a wide range of matrix components, such as microfibrillar protei...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1636812/full |
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| author | Francesco Demetrio Lofaro Alessia Mazzilli Susanna Bonacorsi Daniela Quaglino Federica Boraldi |
| author_facet | Francesco Demetrio Lofaro Alessia Mazzilli Susanna Bonacorsi Daniela Quaglino Federica Boraldi |
| author_sort | Francesco Demetrio Lofaro |
| collection | DOAJ |
| description | In the cardiovascular system, elastic fibres exert a fundamental role providing the long-range elasticity required for physiological functions. Elastic fibres are complex in composition and structure containing, in addition to elastin, a wide range of matrix components, such as microfibrillar proteins, calcium-binding proteins and glycosaminoglycans. Changes in composition and/or structure can affect the biomechanics of the tissue as well as the intrinsic affinity of elastin for Ca2+ ions. Mineralization of elastic fibres can occur in genetic as well as in age-related chronic diseases. In cardiovascular diseases, for instance, calcification represents an integral part of the pathogenetic process, although the regulatory mechanisms are not completely understood. Therefore, a focus is given on elastin synthesis and assembly, on elastic fibre components and on elastin degradation. Moreover, the role and the impact of altered composition and supramolecular organization of elastic fibres are described in the context of the calcified cardiovascular system. Finally, some in vitro and in vivo models of elastic fibres calcification are presented and discussed. |
| format | Article |
| id | doaj-art-c01cbe671ece4d36985b647ed89ab7d8 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-c01cbe671ece4d36985b647ed89ab7d82025-08-25T05:26:25ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-08-011210.3389/fcvm.2025.16368121636812Calcification of the elastic component: the impact on the cardiovascular systemFrancesco Demetrio LofaroAlessia MazzilliSusanna BonacorsiDaniela QuaglinoFederica BoraldiIn the cardiovascular system, elastic fibres exert a fundamental role providing the long-range elasticity required for physiological functions. Elastic fibres are complex in composition and structure containing, in addition to elastin, a wide range of matrix components, such as microfibrillar proteins, calcium-binding proteins and glycosaminoglycans. Changes in composition and/or structure can affect the biomechanics of the tissue as well as the intrinsic affinity of elastin for Ca2+ ions. Mineralization of elastic fibres can occur in genetic as well as in age-related chronic diseases. In cardiovascular diseases, for instance, calcification represents an integral part of the pathogenetic process, although the regulatory mechanisms are not completely understood. Therefore, a focus is given on elastin synthesis and assembly, on elastic fibre components and on elastin degradation. Moreover, the role and the impact of altered composition and supramolecular organization of elastic fibres are described in the context of the calcified cardiovascular system. Finally, some in vitro and in vivo models of elastic fibres calcification are presented and discussed.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1636812/fullelastic fibremineralizationelastocalcinosiscardiovascular systemextracellular matrixcalcification models |
| spellingShingle | Francesco Demetrio Lofaro Alessia Mazzilli Susanna Bonacorsi Daniela Quaglino Federica Boraldi Calcification of the elastic component: the impact on the cardiovascular system Frontiers in Cardiovascular Medicine elastic fibre mineralization elastocalcinosis cardiovascular system extracellular matrix calcification models |
| title | Calcification of the elastic component: the impact on the cardiovascular system |
| title_full | Calcification of the elastic component: the impact on the cardiovascular system |
| title_fullStr | Calcification of the elastic component: the impact on the cardiovascular system |
| title_full_unstemmed | Calcification of the elastic component: the impact on the cardiovascular system |
| title_short | Calcification of the elastic component: the impact on the cardiovascular system |
| title_sort | calcification of the elastic component the impact on the cardiovascular system |
| topic | elastic fibre mineralization elastocalcinosis cardiovascular system extracellular matrix calcification models |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1636812/full |
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