Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis
BackgroundPrevious studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be an effective and safe alternative treatment for post-stroke cognitive impairment (PSCI). Similarly, the application of transcranial direct current stimulation (tDCS) during stroke rehabilitation...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1424792/full |
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| author | Jing Zhao Qian Meng Shuo Qi Hongfei Zhao Ling Xia |
| author_facet | Jing Zhao Qian Meng Shuo Qi Hongfei Zhao Ling Xia |
| author_sort | Jing Zhao |
| collection | DOAJ |
| description | BackgroundPrevious studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be an effective and safe alternative treatment for post-stroke cognitive impairment (PSCI). Similarly, the application of transcranial direct current stimulation (tDCS) during stroke rehabilitation has been shown to improve cognitive function in PSCI patients. However, there have been conflicting results from some studies. Therefore, this study aims to conduct a meta-analysis to evaluate the effects of tDCS and rTMS on PSCI.MethodsThe meta-analysis search for articles published from the initial availability date to 5 February 2024 in databases. The extracted study data were entered into STATA 12.0 software for statistical analysis.ResultsThis meta-analysis provides evidence that both rTMS and tDCS have a positive impact on general cognitive function in PSCI patients [immediate effect of rTMS: standard mean difference (SMD) = 2.58, 95% confidence interval (CI) = 1.44 to 3.71; long-term effect of rTMS: SMD = 2.33, 95% CI = 0.87–3.78; immediate effect of tDCS: SMD = 2.22, 95% CI = 1.31–3.12]. Specifically, rTMS was found to significantly improve attention, language, memory, and visuospatial functions, while it did not show a significant therapeutic effect on executive function (attention: SMD = 3.77, 95% CI = 2.30–5.24; executive function: SMD = −0.52, 95% CI = −3.17–2.12; language: SMD = 3.43, 95% CI = 1.50–5.36; memory: SMD = 3.52, 95% CI = 1.74–5.30; visuospatial function: SMD = 4.71, 95% CI = 2.61–6.80). On the other hand, tDCS was found to significantly improve executive and visuospatial functions but did not show a significant improvement in attention function and memory (attention: SMD = 0.63, 95% CI = −0.30–1.55; executive function: SMD = 2.15, 95% CI = 0.87–3.43; memory: SMD = 0.99, 95% CI = −0.81–2.80; visuospatial function: SMD = 2.64, 95% CI = 1.04–4.23).ConclusionIn conclusion, this meta-analysis demonstrates that both rTMS and tDCS are effective therapeutic techniques for improving cognitive function in PSCI. However, more large-scale studies are needed to further investigate the effects of these techniques on different cognitive domains in PSCI. |
| format | Article |
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| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-c01aff7716e246f98698fc71d8bd32a12025-08-20T01:47:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-10-011510.3389/fneur.2024.14247921424792Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysisJing ZhaoQian MengShuo QiHongfei ZhaoLing XiaBackgroundPrevious studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be an effective and safe alternative treatment for post-stroke cognitive impairment (PSCI). Similarly, the application of transcranial direct current stimulation (tDCS) during stroke rehabilitation has been shown to improve cognitive function in PSCI patients. However, there have been conflicting results from some studies. Therefore, this study aims to conduct a meta-analysis to evaluate the effects of tDCS and rTMS on PSCI.MethodsThe meta-analysis search for articles published from the initial availability date to 5 February 2024 in databases. The extracted study data were entered into STATA 12.0 software for statistical analysis.ResultsThis meta-analysis provides evidence that both rTMS and tDCS have a positive impact on general cognitive function in PSCI patients [immediate effect of rTMS: standard mean difference (SMD) = 2.58, 95% confidence interval (CI) = 1.44 to 3.71; long-term effect of rTMS: SMD = 2.33, 95% CI = 0.87–3.78; immediate effect of tDCS: SMD = 2.22, 95% CI = 1.31–3.12]. Specifically, rTMS was found to significantly improve attention, language, memory, and visuospatial functions, while it did not show a significant therapeutic effect on executive function (attention: SMD = 3.77, 95% CI = 2.30–5.24; executive function: SMD = −0.52, 95% CI = −3.17–2.12; language: SMD = 3.43, 95% CI = 1.50–5.36; memory: SMD = 3.52, 95% CI = 1.74–5.30; visuospatial function: SMD = 4.71, 95% CI = 2.61–6.80). On the other hand, tDCS was found to significantly improve executive and visuospatial functions but did not show a significant improvement in attention function and memory (attention: SMD = 0.63, 95% CI = −0.30–1.55; executive function: SMD = 2.15, 95% CI = 0.87–3.43; memory: SMD = 0.99, 95% CI = −0.81–2.80; visuospatial function: SMD = 2.64, 95% CI = 1.04–4.23).ConclusionIn conclusion, this meta-analysis demonstrates that both rTMS and tDCS are effective therapeutic techniques for improving cognitive function in PSCI. However, more large-scale studies are needed to further investigate the effects of these techniques on different cognitive domains in PSCI.https://www.frontiersin.org/articles/10.3389/fneur.2024.1424792/fullmeta-analysispost-stroke cognitive impairmentrepetitive transcranial magnetic stimulationtranscranial direct current stimulationsystematic review |
| spellingShingle | Jing Zhao Qian Meng Shuo Qi Hongfei Zhao Ling Xia Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis Frontiers in Neurology meta-analysis post-stroke cognitive impairment repetitive transcranial magnetic stimulation transcranial direct current stimulation systematic review |
| title | Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis |
| title_full | Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis |
| title_fullStr | Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis |
| title_full_unstemmed | Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis |
| title_short | Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis |
| title_sort | effect of non invasive brain stimulation on post stroke cognitive impairment a meta analysis |
| topic | meta-analysis post-stroke cognitive impairment repetitive transcranial magnetic stimulation transcranial direct current stimulation systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1424792/full |
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