Research Progress of in the Treatment of Gastrointestinal Cancer
Gastrointestinal (GI) cancer stands as one of the most prevalent forms of cancer globally, presenting a substantial medical and economic burden on cancer treatment. Despite advancements in therapies, it continues to exhibit the second highest mortality rate, primarily attributed to drug resistance a...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-11-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354241302049 |
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| _version_ | 1850219165069082624 |
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| author | Lankang Wang MD Baoyi Ni MD Jia Wang BMed Jilai Zhou BMed Junyi Wang BMed Jiakang Jiang MD Yutong Sui MD Yaoyao Tian MD Feng Gao BMed Yufeng Lyu BMed |
| author_facet | Lankang Wang MD Baoyi Ni MD Jia Wang BMed Jilai Zhou BMed Junyi Wang BMed Jiakang Jiang MD Yutong Sui MD Yaoyao Tian MD Feng Gao BMed Yufeng Lyu BMed |
| author_sort | Lankang Wang MD |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancer stands as one of the most prevalent forms of cancer globally, presenting a substantial medical and economic burden on cancer treatment. Despite advancements in therapies, it continues to exhibit the second highest mortality rate, primarily attributed to drug resistance and post-treatment side effects. There is an urgent need for novel therapeutic approaches to tackle this persistent challenge. Scutellaria baicalensis , widely used in Traditional Chinese Medicine (TCM), holds a profound pharmaceutical legacy. Modern pharmacological studies have unveiled its anticancer, antioxidant, and immune-enhancing properties. S. baicalensis contains hundreds of active ingredients, with flavonoids, polysaccharides, phenylethanoid glycosides, terpenoids, and sterols being the principal components. These constituents contribute to the treatment of GI cancer by inducing apoptosis in tumor cells, arresting the cell cycle, inhibiting tumor proliferation and metastasis, regulating the tumor microenvironment, modulating epigenetics, and reversing drug resistance. Furthermore, the utilization of modern drug delivery technologies can enhance the bioavailability and therapeutic efficacy of TCM. The treatment of GI cancer with S. baicalensis is characterized by its multi-component, multi-target, and multi-pathway advantages, and S. baicalensis has a broad prospect of becoming a clinical adjuvant or even the main therapy for GI cancer. |
| format | Article |
| id | doaj-art-c01609534d794bfba528eb3fcc5b12f7 |
| institution | OA Journals |
| issn | 1552-695X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj-art-c01609534d794bfba528eb3fcc5b12f72025-08-20T02:07:28ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2024-11-012310.1177/15347354241302049Research Progress of in the Treatment of Gastrointestinal CancerLankang Wang MD0Baoyi Ni MD1Jia Wang BMed2Jilai Zhou BMed3Junyi Wang BMed4Jiakang Jiang MD5Yutong Sui MD6Yaoyao Tian MD7Feng Gao BMed8Yufeng Lyu BMed9Heilongjiang University of Chinese Medicine, Harbin, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaHongqi Hospital of Mudanjiang Medical University, Mudanjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaThe First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaShenzhen Hospital of Southern Medical University, Shenzhen, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaMudanjiang Hospital of Chinese Medicine, Mudanjiang, ChinaHongqi Hospital of Mudanjiang Medical University, Mudanjiang, ChinaGastrointestinal (GI) cancer stands as one of the most prevalent forms of cancer globally, presenting a substantial medical and economic burden on cancer treatment. Despite advancements in therapies, it continues to exhibit the second highest mortality rate, primarily attributed to drug resistance and post-treatment side effects. There is an urgent need for novel therapeutic approaches to tackle this persistent challenge. Scutellaria baicalensis , widely used in Traditional Chinese Medicine (TCM), holds a profound pharmaceutical legacy. Modern pharmacological studies have unveiled its anticancer, antioxidant, and immune-enhancing properties. S. baicalensis contains hundreds of active ingredients, with flavonoids, polysaccharides, phenylethanoid glycosides, terpenoids, and sterols being the principal components. These constituents contribute to the treatment of GI cancer by inducing apoptosis in tumor cells, arresting the cell cycle, inhibiting tumor proliferation and metastasis, regulating the tumor microenvironment, modulating epigenetics, and reversing drug resistance. Furthermore, the utilization of modern drug delivery technologies can enhance the bioavailability and therapeutic efficacy of TCM. The treatment of GI cancer with S. baicalensis is characterized by its multi-component, multi-target, and multi-pathway advantages, and S. baicalensis has a broad prospect of becoming a clinical adjuvant or even the main therapy for GI cancer.https://doi.org/10.1177/15347354241302049 |
| spellingShingle | Lankang Wang MD Baoyi Ni MD Jia Wang BMed Jilai Zhou BMed Junyi Wang BMed Jiakang Jiang MD Yutong Sui MD Yaoyao Tian MD Feng Gao BMed Yufeng Lyu BMed Research Progress of in the Treatment of Gastrointestinal Cancer Integrative Cancer Therapies |
| title | Research Progress of in the Treatment of Gastrointestinal Cancer |
| title_full | Research Progress of in the Treatment of Gastrointestinal Cancer |
| title_fullStr | Research Progress of in the Treatment of Gastrointestinal Cancer |
| title_full_unstemmed | Research Progress of in the Treatment of Gastrointestinal Cancer |
| title_short | Research Progress of in the Treatment of Gastrointestinal Cancer |
| title_sort | research progress of in the treatment of gastrointestinal cancer |
| url | https://doi.org/10.1177/15347354241302049 |
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