Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series
Abstract Background The EyeCee® ONE intraocular lens (Nidek, Gamagori, Japan) has been withdrawn from the market due to a high number of reports of severe ocular hypertension (OHT) following phacoemulsification with implantation of this intraocular lens (IOL). In this case series, we report the resu...
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BMC
2024-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03810-1 |
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| author | Paul Bastelica Romain Magny Joël Poupon Bertrand Sonigo Tristan Aubert Françoise Brignole-Baudouin Juliette Buffault Christophe Baudouin Antoine Labbé |
| author_facet | Paul Bastelica Romain Magny Joël Poupon Bertrand Sonigo Tristan Aubert Françoise Brignole-Baudouin Juliette Buffault Christophe Baudouin Antoine Labbé |
| author_sort | Paul Bastelica |
| collection | DOAJ |
| description | Abstract Background The EyeCee® ONE intraocular lens (Nidek, Gamagori, Japan) has been withdrawn from the market due to a high number of reports of severe ocular hypertension (OHT) following phacoemulsification with implantation of this intraocular lens (IOL). In this case series, we report the results of a toxicological analysis and the surgical management of five patients with severe OHT following the implantation of defective EyeCee® ONE IOLs during cataract surgery. Cases presentation Five patients developed early, severe OHT refractory to maximal medical therapy following uneventful phacoemulsification (PCE) cataract surgery with implantation of an EyeCee® ONE IOL from a defective lot. Glaucoma filtering surgeries were required to control intraocular pressure (IOP). Toxicological analyses were carried out on the aqueous humor of one patient. IOP levels were monitored during postoperative follow-up, but three patients required postoperative adjustments (reintroduction of IOP-lowering therapy, goniopuncture or needling) in order to maintain IOP at satisfactory levels. Toxicological analysis revealed a high concentration of silicon in the aqueous humor of the patient from whom the sample was obtained. Conclusions These cases of OHT following cataract surgery with a defective IOL were of early onset severe, all requiring filtering surgery. The exact mechanism of this OHT has not been determined, but we did find high concentrations of silicon in the aqueous humor of one of these patients. Patients who received EyeCee® ONE IOLs during the same period of time should have their IOP and optic nerve monitored to detect any potential OHT or glaucoma that might appear over time. |
| format | Article |
| id | doaj-art-c014cf39dc064d3d989d014fcba2ec9b |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-c014cf39dc064d3d989d014fcba2ec9b2024-12-22T12:22:03ZengBMCBMC Ophthalmology1471-24152024-12-012411510.1186/s12886-024-03810-1Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case seriesPaul Bastelica0Romain Magny1Joël Poupon2Bertrand Sonigo3Tristan Aubert4Françoise Brignole-Baudouin5Juliette Buffault6Christophe Baudouin7Antoine Labbé8Department 3, 15-20 National Vision Hospital, IHU FOReSIGHTToxicology-Biology Department, Saint-Louis - Lariboisière - Fernand Widal GroupToxicology-Biology Department, Saint-Louis - Lariboisière - Fernand Widal GroupSaint Germain Vision Eye CenterDepartment 3, 15-20 National Vision Hospital, IHU FOReSIGHTDepartment 3, 15-20 National Vision Hospital, IHU FOReSIGHTDepartment 3, 15-20 National Vision Hospital, IHU FOReSIGHTDepartment 3, 15-20 National Vision Hospital, IHU FOReSIGHTDepartment 3, 15-20 National Vision Hospital, IHU FOReSIGHTAbstract Background The EyeCee® ONE intraocular lens (Nidek, Gamagori, Japan) has been withdrawn from the market due to a high number of reports of severe ocular hypertension (OHT) following phacoemulsification with implantation of this intraocular lens (IOL). In this case series, we report the results of a toxicological analysis and the surgical management of five patients with severe OHT following the implantation of defective EyeCee® ONE IOLs during cataract surgery. Cases presentation Five patients developed early, severe OHT refractory to maximal medical therapy following uneventful phacoemulsification (PCE) cataract surgery with implantation of an EyeCee® ONE IOL from a defective lot. Glaucoma filtering surgeries were required to control intraocular pressure (IOP). Toxicological analyses were carried out on the aqueous humor of one patient. IOP levels were monitored during postoperative follow-up, but three patients required postoperative adjustments (reintroduction of IOP-lowering therapy, goniopuncture or needling) in order to maintain IOP at satisfactory levels. Toxicological analysis revealed a high concentration of silicon in the aqueous humor of the patient from whom the sample was obtained. Conclusions These cases of OHT following cataract surgery with a defective IOL were of early onset severe, all requiring filtering surgery. The exact mechanism of this OHT has not been determined, but we did find high concentrations of silicon in the aqueous humor of one of these patients. Patients who received EyeCee® ONE IOLs during the same period of time should have their IOP and optic nerve monitored to detect any potential OHT or glaucoma that might appear over time.https://doi.org/10.1186/s12886-024-03810-1GlaucomaOcular hypertensionPhacoemulsificationIntraocular lensToxicology |
| spellingShingle | Paul Bastelica Romain Magny Joël Poupon Bertrand Sonigo Tristan Aubert Françoise Brignole-Baudouin Juliette Buffault Christophe Baudouin Antoine Labbé Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series BMC Ophthalmology Glaucoma Ocular hypertension Phacoemulsification Intraocular lens Toxicology |
| title | Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series |
| title_full | Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series |
| title_fullStr | Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series |
| title_full_unstemmed | Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series |
| title_short | Management and toxicological analysis of ocular hypertension after EyeCee® ONE intraocular lens implantation: a case series |
| title_sort | management and toxicological analysis of ocular hypertension after eyecee r one intraocular lens implantation a case series |
| topic | Glaucoma Ocular hypertension Phacoemulsification Intraocular lens Toxicology |
| url | https://doi.org/10.1186/s12886-024-03810-1 |
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