Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial
Abstract Women with pre-existing sleep disturbance frequently experience postoperative sleep disturbance after surgery. This randomized, double-blind, placebo-controlled, parallel-group trial was conducted to investigate the efficacy of intraoperative adjunctive esketamine administration in the redu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62933-1 |
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| author | Zhenhua Song Miao Miao Fei Huang Lingyue Hu Xinyu Yang Wei Cui Yonghao Yu Guolin Wang Chunyan Wang Linlin Zhang |
| author_facet | Zhenhua Song Miao Miao Fei Huang Lingyue Hu Xinyu Yang Wei Cui Yonghao Yu Guolin Wang Chunyan Wang Linlin Zhang |
| author_sort | Zhenhua Song |
| collection | DOAJ |
| description | Abstract Women with pre-existing sleep disturbance frequently experience postoperative sleep disturbance after surgery. This randomized, double-blind, placebo-controlled, parallel-group trial was conducted to investigate the efficacy of intraoperative adjunctive esketamine administration in the reduction of postoperative sleep disturbance following surgical abortion for women with pre-existing sleep disturbance. 204 women who had sleep disturbance and were scheduled for elective surgical abortion were randomized in a one-to-one allocation ratio to receive either a single intravenous injection of 0.2 mg/kg of esketamine or placebo (saline) immediately after the beginning of surgery (102 women allocated to each group). This trial has now completed. The primary outcome, incidence of sleep disturbance on the first night after surgery, is significantly lower in the esketamine group than in the placebo group (47.1% [48 of 102] vs 71.6% [73 of 102]; odds ratio, 0.35; 95%CI, 0.20–0.64; P = 0.0004). No treatment-related serious adverse events were observed. Here we show that a single low dose of esketamine during surgical abortion improves postoperative sleep quality for women with pre-existing sleep disturbance. ClinicalTrials.gov identifier: NCT06388824. |
| format | Article |
| id | doaj-art-c013e1f951c7496482c3011f9453b8a2 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-c013e1f951c7496482c3011f9453b8a22025-08-20T03:05:14ZengNature PortfolioNature Communications2041-17232025-08-0116111010.1038/s41467-025-62933-1Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trialZhenhua Song0Miao Miao1Fei Huang2Lingyue Hu3Xinyu Yang4Wei Cui5Yonghao Yu6Guolin Wang7Chunyan Wang8Linlin Zhang9Department of Anesthesiology, Tianjin Medical University General HospitalDepartment of Gynecology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalDepartment of Anesthesiology, Tianjin Medical University General HospitalAbstract Women with pre-existing sleep disturbance frequently experience postoperative sleep disturbance after surgery. This randomized, double-blind, placebo-controlled, parallel-group trial was conducted to investigate the efficacy of intraoperative adjunctive esketamine administration in the reduction of postoperative sleep disturbance following surgical abortion for women with pre-existing sleep disturbance. 204 women who had sleep disturbance and were scheduled for elective surgical abortion were randomized in a one-to-one allocation ratio to receive either a single intravenous injection of 0.2 mg/kg of esketamine or placebo (saline) immediately after the beginning of surgery (102 women allocated to each group). This trial has now completed. The primary outcome, incidence of sleep disturbance on the first night after surgery, is significantly lower in the esketamine group than in the placebo group (47.1% [48 of 102] vs 71.6% [73 of 102]; odds ratio, 0.35; 95%CI, 0.20–0.64; P = 0.0004). No treatment-related serious adverse events were observed. Here we show that a single low dose of esketamine during surgical abortion improves postoperative sleep quality for women with pre-existing sleep disturbance. ClinicalTrials.gov identifier: NCT06388824.https://doi.org/10.1038/s41467-025-62933-1 |
| spellingShingle | Zhenhua Song Miao Miao Fei Huang Lingyue Hu Xinyu Yang Wei Cui Yonghao Yu Guolin Wang Chunyan Wang Linlin Zhang Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial Nature Communications |
| title | Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial |
| title_full | Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial |
| title_fullStr | Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial |
| title_full_unstemmed | Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial |
| title_short | Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial |
| title_sort | effect of a single low dose esketamine administration during surgical abortion on postoperative sleep disturbance a randomized controlled trial |
| url | https://doi.org/10.1038/s41467-025-62933-1 |
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