Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing
Eighty percent of asthma attacks in children are accompanied by an upper respiratory tract viral infection. Adenovirus is one of the major viral causes of childhood bronchiolitis. As the polymerase chain reaction (PCR) is the most sensitive technique for documenting viral respiratory infectio...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2005-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2719 |
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| _version_ | 1850237050959167488 |
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| author | Cansin Saçkesen Ahmet Pinar Bülent E Sekerel Yakut Akyön Yildiz Saraçlar |
| author_facet | Cansin Saçkesen Ahmet Pinar Bülent E Sekerel Yakut Akyön Yildiz Saraçlar |
| author_sort | Cansin Saçkesen |
| collection | DOAJ |
| description |
Eighty percent of asthma attacks in children are accompanied by an upper respiratory tract viral infection. Adenovirus is one of the major viral causes of childhood bronchiolitis. As the polymerase chain reaction (PCR) is the most sensitive technique for documenting viral respiratory infections, the PCR method was performed on the throat swab samples of asthmatic children with and without wheezing to investigate the presence of the adenovirus genome in the upper respiratory tract. The frequencies of adenovirus in asymptomatic and symptomatic asthmatic patients, healthy controls and wheezy children were as follows: 33.3%, 71.4%, 37% and 62.96%, respectively. The adenovirus was detected in a significantly higher percentage in the upper airways of patients with asthma exacerbation and in children with wheezing than in patients without asthma exacerbation and in the healthy controls (p < 0.05). The frequency of adenovirus was not different between asthmatic patients receiving or not receiving inhaled corticosteroid. Adenovirus has the potential to precipitate asthma exacerbations in asthmatic patients; its frequency was not affected by the treatment of inhaled corticosteroid.
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| format | Article |
| id | doaj-art-c0128e6a644f4c88a192be6e5bf47f2a |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2005-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-c0128e6a644f4c88a192be6e5bf47f2a2025-08-20T02:01:50ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212005-07-01473Use of polymerase chain reaction for detection of adenovirus in children with or without wheezingCansin Saçkesen0Ahmet PinarBülent E SekerelYakut AkyönYildiz SaraçlarDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Eighty percent of asthma attacks in children are accompanied by an upper respiratory tract viral infection. Adenovirus is one of the major viral causes of childhood bronchiolitis. As the polymerase chain reaction (PCR) is the most sensitive technique for documenting viral respiratory infections, the PCR method was performed on the throat swab samples of asthmatic children with and without wheezing to investigate the presence of the adenovirus genome in the upper respiratory tract. The frequencies of adenovirus in asymptomatic and symptomatic asthmatic patients, healthy controls and wheezy children were as follows: 33.3%, 71.4%, 37% and 62.96%, respectively. The adenovirus was detected in a significantly higher percentage in the upper airways of patients with asthma exacerbation and in children with wheezing than in patients without asthma exacerbation and in the healthy controls (p < 0.05). The frequency of adenovirus was not different between asthmatic patients receiving or not receiving inhaled corticosteroid. Adenovirus has the potential to precipitate asthma exacerbations in asthmatic patients; its frequency was not affected by the treatment of inhaled corticosteroid. https://turkjpediatr.org/article/view/2719 |
| spellingShingle | Cansin Saçkesen Ahmet Pinar Bülent E Sekerel Yakut Akyön Yildiz Saraçlar Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing The Turkish Journal of Pediatrics |
| title | Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| title_full | Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| title_fullStr | Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| title_full_unstemmed | Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| title_short | Use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| title_sort | use of polymerase chain reaction for detection of adenovirus in children with or without wheezing |
| url | https://turkjpediatr.org/article/view/2719 |
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