Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis
Physical anatomical models constructed from medical images are valuable research tools for evaluating patient-specific clinical circumstances. For example, 3D models replicating a patient's internal anatomy in the cardiovascular system can be used to validate Computational Fluid Dynamics (CFD)...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | MethodsX |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215016124005752 |
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| author | Jarrett Fowler Andrew B. Robbins Cathryn Gunawan Andrew Jastram Michael Moreno |
| author_facet | Jarrett Fowler Andrew B. Robbins Cathryn Gunawan Andrew Jastram Michael Moreno |
| author_sort | Jarrett Fowler |
| collection | DOAJ |
| description | Physical anatomical models constructed from medical images are valuable research tools for evaluating patient-specific clinical circumstances. For example, 3D models replicating a patient's internal anatomy in the cardiovascular system can be used to validate Computational Fluid Dynamics (CFD) models, which can then be used to identify potential hemodynamic consequences of surgical decisions by providing insight into how blood and vascular tissue mechanics may contribute to disease progression and post-operative complications. Patient-specific models have been described in the literature; however, rapid prototyping models that achieve anatomical accuracy, optical transparency, and thin-walled compliance in a cost and time-effective approach have proven challenging. This limits their utility for modeling flows in vessels, e.g., the aorta, where compliance is particularly important. The work described herein is focused on a unique design and fabrication process implemented to produce physical patient-specific models that replicate the original anatomy dimensions and compliance with optical properties consistent with clinical imaging techniques. The patient-specific models are produced for under $150 of easily accessible consumable raw materials within 30 h using a relatively basic approach. • This method can be tuned for anatomies with different shapes and compliance. • This method can produce models to investigate medical device performance in vitro. |
| format | Article |
| id | doaj-art-c00c827c1f41497baef1cf8352cf55d1 |
| institution | Kabale University |
| issn | 2215-0161 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj-art-c00c827c1f41497baef1cf8352cf55d12025-08-20T03:24:11ZengElsevierMethodsX2215-01612025-06-011410312410.1016/j.mex.2024.103124Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow AnalysisJarrett Fowler0Andrew B. Robbins1Cathryn Gunawan2Andrew Jastram3Michael Moreno4Texas A&M University Department of Biomedical Engineering, College Station, TX 77840, US; Rice University Department of Bioengineering, Houston, TX 77030, US; Corresponding author.University of Texas at Tyler Department of Mechanical Engineering, Tyler, TX 75799, US; J. Mike Walker ’66 Department of Mechanical Engineering, College Station, TX 77840, US; Texas A&M University Department of Multi-Disciplinary Engineering, Houston, TX 77840, USTexas A&M University Department of Biomedical Engineering, College Station, TX 77840, USJ. Mike Walker ’66 Department of Mechanical Engineering, College Station, TX 77840, USTexas A&M University Department of Biomedical Engineering, College Station, TX 77840, US; J. Mike Walker ’66 Department of Mechanical Engineering, College Station, TX 77840, US; Texas A&M University School of Engineering Medicine, Houston, TX 77030, USPhysical anatomical models constructed from medical images are valuable research tools for evaluating patient-specific clinical circumstances. For example, 3D models replicating a patient's internal anatomy in the cardiovascular system can be used to validate Computational Fluid Dynamics (CFD) models, which can then be used to identify potential hemodynamic consequences of surgical decisions by providing insight into how blood and vascular tissue mechanics may contribute to disease progression and post-operative complications. Patient-specific models have been described in the literature; however, rapid prototyping models that achieve anatomical accuracy, optical transparency, and thin-walled compliance in a cost and time-effective approach have proven challenging. This limits their utility for modeling flows in vessels, e.g., the aorta, where compliance is particularly important. The work described herein is focused on a unique design and fabrication process implemented to produce physical patient-specific models that replicate the original anatomy dimensions and compliance with optical properties consistent with clinical imaging techniques. The patient-specific models are produced for under $150 of easily accessible consumable raw materials within 30 h using a relatively basic approach. • This method can be tuned for anatomies with different shapes and compliance. • This method can produce models to investigate medical device performance in vitro.http://www.sciencedirect.com/science/article/pii/S2215016124005752Fabrication Method of Patient-Specific Cardiovascular Phantom Models for Experimental Fluid Flow Analysis |
| spellingShingle | Jarrett Fowler Andrew B. Robbins Cathryn Gunawan Andrew Jastram Michael Moreno Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis MethodsX Fabrication Method of Patient-Specific Cardiovascular Phantom Models for Experimental Fluid Flow Analysis |
| title | Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis |
| title_full | Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis |
| title_fullStr | Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis |
| title_full_unstemmed | Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis |
| title_short | Rapid Manufacturing Method of Cardiovascular Models for Experimental Flow Analysis |
| title_sort | rapid manufacturing method of cardiovascular models for experimental flow analysis |
| topic | Fabrication Method of Patient-Specific Cardiovascular Phantom Models for Experimental Fluid Flow Analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2215016124005752 |
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