Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence

Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence

Follicles (Fs)/Germinal Centers (GCs) in tonsils and lymph nodes are dynamic microenvironments where diverse immune cell populations interact for the development of antibody responses against pathogens. The accurate in situ phenotypic analysis of these immune cells is a prerequisite for the comphehe...

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Bibliographic Details
Main Authors: Simon Burgermeister, Michail Orfanakis, Spiros Georgakis, Cloe Brenna, Helen Lindsay, Craig Fenwick, Giuseppe Pantaleo, Raphael Gottardo, Constantinos Petrovas
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biology
Subjects:
multiplex immunofluorescence
unsupervised clustering
germinal centers
Online Access:https://www.mdpi.com/2079-7737/14/5/530
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