Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Abstract INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data (n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25–101 y). We measured cognitive decline across two dec...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70038 |
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| author | Micah J. Savin Haoyang Wang Heming Pei Allison E. Aiello Stephanie Assuras Avshalom Caspi Terrie E. Moffitt Peter A. Muenning Calen P. Ryan Baoyi Shi Yaakov Stern Karen Sugden Linda Valeri Daniel W. Belsky |
| author_facet | Micah J. Savin Haoyang Wang Heming Pei Allison E. Aiello Stephanie Assuras Avshalom Caspi Terrie E. Moffitt Peter A. Muenning Calen P. Ryan Baoyi Shi Yaakov Stern Karen Sugden Linda Valeri Daniel W. Belsky |
| author_sort | Micah J. Savin |
| collection | DOAJ |
| description | Abstract INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data (n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25–101 y). We measured cognitive decline across two decades of neuropsychological‐testing follow‐up. We measured pace of aging using the DunedinPACE epigenetic clock. Analysis tested if participants with faster DunedinPACE values experienced more rapid cognitive decline compared with those with slower DunedinPACE values. RESULTS Participants with faster DunedinPACE had poorer cognitive functioning at baseline and experienced more rapid cognitive decline over follow‐up. Results were robust to confounders and consistent across population strata. Findings were similar for the PhenoAge and GrimAge epigenetic clocks. DISCUSSION Faster pace of aging is a risk factor for preclinical cognitive decline. Metrics of biological aging may inform risk stratification in clinical trials and prognosis in patient care. Highlights Faster DunedinPACE is associated with preclinical cognitive aging. Higher baseline cognition was protective of DunedinPACE‐associated cognitive decline. The DunedinPACE association with cognitive decline explained a fourth of dementia risk. |
| format | Article |
| id | doaj-art-c00813b213fc413fbd7aa79a23f5c2c9 |
| institution | DOAJ |
| issn | 2352-8729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-c00813b213fc413fbd7aa79a23f5c2c92025-08-20T02:55:53ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-10-01164n/an/a10.1002/dad2.70038Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring CohortMicah J. Savin0Haoyang Wang1Heming Pei2Allison E. Aiello3Stephanie Assuras4Avshalom Caspi5Terrie E. Moffitt6Peter A. Muenning7Calen P. Ryan8Baoyi Shi9Yaakov Stern10Karen Sugden11Linda Valeri12Daniel W. Belsky13Robert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USARobert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USARobert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USARobert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USANeuropsychology Department of Neurology Columbia University Irving Medical Center New York New York USADepartment of Psychology & Neuroscience Trinity College of Arts & Sciences Duke University Durham North Carolina USADepartment of Psychology & Neuroscience Trinity College of Arts & Sciences Duke University Durham North Carolina USAHealth Policy and Management Mailman School of Public Health Columbia University Irving Medical Center New York New York USARobert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USADepartment of Biostatistics MSPH Columbia University Irving Medical Center New York New York USAGH Sergievsky Center Department of Neurology Columbia University Irving Medical Center New York New York USADepartment of Psychology & Neuroscience Trinity College of Arts & Sciences Duke University Durham North Carolina USADepartment of Biostatistics MSPH Columbia University Irving Medical Center New York New York USARobert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USAAbstract INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data (n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25–101 y). We measured cognitive decline across two decades of neuropsychological‐testing follow‐up. We measured pace of aging using the DunedinPACE epigenetic clock. Analysis tested if participants with faster DunedinPACE values experienced more rapid cognitive decline compared with those with slower DunedinPACE values. RESULTS Participants with faster DunedinPACE had poorer cognitive functioning at baseline and experienced more rapid cognitive decline over follow‐up. Results were robust to confounders and consistent across population strata. Findings were similar for the PhenoAge and GrimAge epigenetic clocks. DISCUSSION Faster pace of aging is a risk factor for preclinical cognitive decline. Metrics of biological aging may inform risk stratification in clinical trials and prognosis in patient care. Highlights Faster DunedinPACE is associated with preclinical cognitive aging. Higher baseline cognition was protective of DunedinPACE‐associated cognitive decline. The DunedinPACE association with cognitive decline explained a fourth of dementia risk.https://doi.org/10.1002/dad2.70038agingAlzheimer's disease and related dementiasbiological agingcognitive declineDunedinPACEepigenetic clocks |
| spellingShingle | Micah J. Savin Haoyang Wang Heming Pei Allison E. Aiello Stephanie Assuras Avshalom Caspi Terrie E. Moffitt Peter A. Muenning Calen P. Ryan Baoyi Shi Yaakov Stern Karen Sugden Linda Valeri Daniel W. Belsky Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring aging Alzheimer's disease and related dementias biological aging cognitive decline DunedinPACE epigenetic clocks |
| title | Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort |
| title_full | Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort |
| title_fullStr | Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort |
| title_full_unstemmed | Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort |
| title_short | Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort |
| title_sort | association of a pace of aging epigenetic clock with rate of cognitive decline in the framingham heart study offspring cohort |
| topic | aging Alzheimer's disease and related dementias biological aging cognitive decline DunedinPACE epigenetic clocks |
| url | https://doi.org/10.1002/dad2.70038 |
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