Systemic and Local Immunological Markers in Preeclampsia
Preeclampsia (PE) is one of the main causes of obstetric complications and leads to both maternal and neonatal mortality. The maternal innate immune system plays an important role throughout pregnancy by providing protection against pathogens, while simultaneously inducing tolerance to a semi-alloge...
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MDPI AG
2025-06-01
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| author | Almagul Kurmanova Altynay Nurmakova Damilya Salimbayeva Gulfiruz Urazbayeva Gaukhar Kurmanova Natalya Kravtsova Zhanar Kypshakbayeva Madina Khalmirzaeva |
| author_facet | Almagul Kurmanova Altynay Nurmakova Damilya Salimbayeva Gulfiruz Urazbayeva Gaukhar Kurmanova Natalya Kravtsova Zhanar Kypshakbayeva Madina Khalmirzaeva |
| author_sort | Almagul Kurmanova |
| collection | DOAJ |
| description | Preeclampsia (PE) is one of the main causes of obstetric complications and leads to both maternal and neonatal mortality. The maternal innate immune system plays an important role throughout pregnancy by providing protection against pathogens, while simultaneously inducing tolerance to a semi-allogenic developing fetus and placental development. <b>Background/Objectives</b>: To conduct a comparative study of immunological markers in the blood and placenta in preeclampsia. <b>Methods</b>: A total of 35 pregnant women were enrolled in a comparative study with preeclampsia (7) and with physiological pregnancy (28). A study of the immune status in peripheral blood and placenta was conducted with an examination of the subpopulation of lymphocytes profile and intracellular cytokines production by flow cytometry. <b>Results</b>: In the blood of pregnant women with PE, there was a decrease in CD14+ monocytes, as well as a significant increase of natural killers CD16+, CD56+ and activation markers HLA-DR+ and CD95+, as well as a significant rise in production of IL-10, TNF, Perforin, GM-CSF, and IGF. At the same time, in placental tissue in patients with preeclampsia, on the contrary, a significant decrease in regulatory cells CD4+, CD8+, CD14+, CD56+, CD59+, activation markers CD95+, as well as anti-inflammatory cytokine IL-10, growth factors VEGFR and IGF was detected. <b>Conclusions</b>: The maternal–fetal immune profile is crucial for successful fetal development and dysregulation of T-, B-, and NK cells can contribute to inflammation, oxidative stress, and the development of preeclampsia. |
| format | Article |
| id | doaj-art-bffd94b35d94451b8d8a3a2960cd8093 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-bffd94b35d94451b8d8a3a2960cd80932025-08-20T03:50:17ZengMDPI AGDiagnostics2075-44182025-06-011513164410.3390/diagnostics15131644Systemic and Local Immunological Markers in PreeclampsiaAlmagul Kurmanova0Altynay Nurmakova1Damilya Salimbayeva2Gulfiruz Urazbayeva3Gaukhar Kurmanova4Natalya Kravtsova5Zhanar Kypshakbayeva6Madina Khalmirzaeva7Department of Obstetrics and Gynecology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, KazakhstanDepartment of Strategic Development and Science, Scientific Center for Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, KazakhstanDepartment of Strategic Development and Science, Scientific Center for Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, KazakhstanDepartment of Strategic Development and Science, Scientific Center for Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, KazakhstanDepartment of Obstetrics and Gynecology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, KazakhstanDepartment of Strategic Development and Science, Scientific Center for Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, KazakhstanDepartment of Obstetrics and Gynecology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, KazakhstanDepartment of Obstetrics and Gynecology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, KazakhstanPreeclampsia (PE) is one of the main causes of obstetric complications and leads to both maternal and neonatal mortality. The maternal innate immune system plays an important role throughout pregnancy by providing protection against pathogens, while simultaneously inducing tolerance to a semi-allogenic developing fetus and placental development. <b>Background/Objectives</b>: To conduct a comparative study of immunological markers in the blood and placenta in preeclampsia. <b>Methods</b>: A total of 35 pregnant women were enrolled in a comparative study with preeclampsia (7) and with physiological pregnancy (28). A study of the immune status in peripheral blood and placenta was conducted with an examination of the subpopulation of lymphocytes profile and intracellular cytokines production by flow cytometry. <b>Results</b>: In the blood of pregnant women with PE, there was a decrease in CD14+ monocytes, as well as a significant increase of natural killers CD16+, CD56+ and activation markers HLA-DR+ and CD95+, as well as a significant rise in production of IL-10, TNF, Perforin, GM-CSF, and IGF. At the same time, in placental tissue in patients with preeclampsia, on the contrary, a significant decrease in regulatory cells CD4+, CD8+, CD14+, CD56+, CD59+, activation markers CD95+, as well as anti-inflammatory cytokine IL-10, growth factors VEGFR and IGF was detected. <b>Conclusions</b>: The maternal–fetal immune profile is crucial for successful fetal development and dysregulation of T-, B-, and NK cells can contribute to inflammation, oxidative stress, and the development of preeclampsia.https://www.mdpi.com/2075-4418/15/13/1644pre-eclampsiaimmune systemplacentamaternal medicinecytokines |
| spellingShingle | Almagul Kurmanova Altynay Nurmakova Damilya Salimbayeva Gulfiruz Urazbayeva Gaukhar Kurmanova Natalya Kravtsova Zhanar Kypshakbayeva Madina Khalmirzaeva Systemic and Local Immunological Markers in Preeclampsia Diagnostics pre-eclampsia immune system placenta maternal medicine cytokines |
| title | Systemic and Local Immunological Markers in Preeclampsia |
| title_full | Systemic and Local Immunological Markers in Preeclampsia |
| title_fullStr | Systemic and Local Immunological Markers in Preeclampsia |
| title_full_unstemmed | Systemic and Local Immunological Markers in Preeclampsia |
| title_short | Systemic and Local Immunological Markers in Preeclampsia |
| title_sort | systemic and local immunological markers in preeclampsia |
| topic | pre-eclampsia immune system placenta maternal medicine cytokines |
| url | https://www.mdpi.com/2075-4418/15/13/1644 |
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