Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are useful in the treatment of metastatic renal cell carcinoma. ICIs have been associated with a variety of immune‐related adverse events (irAEs), one of which is a sarcoid‐like reaction (SLR). SLR is often difficult to distinguish from cance...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.70027 |
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| author | Kanta Fukushima Sota Mizukoshi Tomohiro Ino Takuya Ishida Yumika Ito Akira Okimura Munehide Nakatsugawa Takeshi Hashimoto |
| author_facet | Kanta Fukushima Sota Mizukoshi Tomohiro Ino Takuya Ishida Yumika Ito Akira Okimura Munehide Nakatsugawa Takeshi Hashimoto |
| author_sort | Kanta Fukushima |
| collection | DOAJ |
| description | ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are useful in the treatment of metastatic renal cell carcinoma. ICIs have been associated with a variety of immune‐related adverse events (irAEs), one of which is a sarcoid‐like reaction (SLR). SLR is often difficult to distinguish from cancer progression. Case Presentation The patient is a 71‐year‐old woman. She underwent laparoscopic nephrectomy after 4 courses of ipilimumab + nivolumab therapy for clear cell renal cell carcinoma with femoral bone metastasis. In the pathological examination, in addition to tumor‐infiltrating lymphocytes, numerous non‐caseating epithelioid cell granulomas were found in the tumor. The occurrence of non‐caseating epithelioid cell granuloma in a patient who did not meet the diagnostic criteria for systemic sarcoidosis was considered SLR due to ICI. Conclusions We report the first case of a patient who underwent surgery for metastatic renal cell carcinoma after treatment with ICI and who was pathologically diagnosed with SLR in the kidney. |
| format | Article |
| id | doaj-art-bff80ec0b98541f68022e75d544ea159 |
| institution | OA Journals |
| issn | 2577-171X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj-art-bff80ec0b98541f68022e75d544ea1592025-08-20T02:14:49ZengWileyIJU Case Reports2577-171X2025-05-018328528810.1002/iju5.70027Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell CarcinomaKanta Fukushima0Sota Mizukoshi1Tomohiro Ino2Takuya Ishida3Yumika Ito4Akira Okimura5Munehide Nakatsugawa6Takeshi Hashimoto7Department of Urology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Urology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Urology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Urology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center Tokyo JapanDepartment of Urology Tokyo Medical University Hachioji Medical Center Tokyo JapanABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are useful in the treatment of metastatic renal cell carcinoma. ICIs have been associated with a variety of immune‐related adverse events (irAEs), one of which is a sarcoid‐like reaction (SLR). SLR is often difficult to distinguish from cancer progression. Case Presentation The patient is a 71‐year‐old woman. She underwent laparoscopic nephrectomy after 4 courses of ipilimumab + nivolumab therapy for clear cell renal cell carcinoma with femoral bone metastasis. In the pathological examination, in addition to tumor‐infiltrating lymphocytes, numerous non‐caseating epithelioid cell granulomas were found in the tumor. The occurrence of non‐caseating epithelioid cell granuloma in a patient who did not meet the diagnostic criteria for systemic sarcoidosis was considered SLR due to ICI. Conclusions We report the first case of a patient who underwent surgery for metastatic renal cell carcinoma after treatment with ICI and who was pathologically diagnosed with SLR in the kidney.https://doi.org/10.1002/iju5.70027immune checkpoint inhibitorimmune‐related adverse eventrenal cell carcinomasarcoid‐like reaction |
| spellingShingle | Kanta Fukushima Sota Mizukoshi Tomohiro Ino Takuya Ishida Yumika Ito Akira Okimura Munehide Nakatsugawa Takeshi Hashimoto Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma IJU Case Reports immune checkpoint inhibitor immune‐related adverse event renal cell carcinoma sarcoid‐like reaction |
| title | Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma |
| title_full | Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma |
| title_fullStr | Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma |
| title_full_unstemmed | Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma |
| title_short | Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma |
| title_sort | sarcoid like reaction slr associated with immune checkpoint inhibitors in metastatic renal cell carcinoma |
| topic | immune checkpoint inhibitor immune‐related adverse event renal cell carcinoma sarcoid‐like reaction |
| url | https://doi.org/10.1002/iju5.70027 |
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