Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities

Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities

Abstract Endometrial carcinoma (EC), the most common gynecologic cancer type in developed countries, encompasses four molecular subtypes (POLEmut, MMRd, p53abn, and NSMP) that have prognostic values and guide treatment decisions. Additionally, dual loss of ARID1A and ARID1B (referred to as ARID1A/B)...

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Main Authors: Eunice S. Li, Rebecca Ho, Ran Tao, Yannes Wai Yan Choi, Chae Young Shin, Shary Y. Chen, Bengul Gokbayrak, Janine Senz, Betty Yao, Liam Johnston, Spencer D. Martin, Eric Yang, Mark S. Carey, Bryan T. Hennessy, David G. Huntsman, Ramon I. Klein Geltink, Lynn Hoang, Yemin Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01053-x
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