Transient clitoromegaly in an extremely preterm twin infant with popliteal pterygium
Clitoromegaly can be congenital or acquired, and it is usually associated with exposure to androgen excess. Pathophysiological mechanisms responsible for transient clitoromegaly in premature female infants have not been fully elucidated. Herein, we present the case of an extremely premature female t...
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Termedia Publishing House
2024-09-01
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| Series: | Pediatric Endocrinology, Diabetes and Metabolism |
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| Online Access: | https://www.termedia.pl/Transient-clitoromegaly-in-an-extremely-preterm-twin-infant-with-popliteal-r-npterygium,138,54678,1,1.html |
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| author | Lavinia La Grasta Sabolić Ana Kovačević Lucija Ana Trtanj Bernardica Valent Morić Jasna Tumbri |
| author_facet | Lavinia La Grasta Sabolić Ana Kovačević Lucija Ana Trtanj Bernardica Valent Morić Jasna Tumbri |
| author_sort | Lavinia La Grasta Sabolić |
| collection | DOAJ |
| description | Clitoromegaly can be congenital or acquired, and it is usually associated with exposure to androgen excess. Pathophysiological mechanisms responsible for transient clitoromegaly in premature female infants have not been fully elucidated. Herein, we present the case of an extremely premature female twin infant, with an extensive web of skin on the back of the left leg, hypoplastic left labia majora, and normal clitoris appearance at birth. At the age of 48 days, clitoral enlargement was observed. Significantly elevated levels of gonadotropins, testosterone, and dehydroepiandrosterone sulphate (DHEAS) were recorded. 17-hydroxyprogesterone (17OHP) was unremarkable, and anti-Müllerian hormone (AMH) was low, in accordance with normal female karyotype. Ovaries were not visualised ultrasonographically. During the following weeks, gradual normalisation of gonadotropin, testosterone, and DHEAS levels was accompanied by regression of clitoromegaly. As described in this case, transient clitoral enlargement may appear in extremely premature female infants due to transitory elevated androgens of ovarian and adrenal origin. |
| format | Article |
| id | doaj-art-bff31117f60543268a42a31116470373 |
| institution | Kabale University |
| issn | 2081-237X 2083-8441 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Termedia Publishing House |
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| series | Pediatric Endocrinology, Diabetes and Metabolism |
| spelling | doaj-art-bff31117f60543268a42a311164703732025-01-27T12:43:44ZengTermedia Publishing HousePediatric Endocrinology, Diabetes and Metabolism2081-237X2083-84412024-09-0130316316710.5114/pedm.2024.14258554678Transient clitoromegaly in an extremely preterm twin infant with popliteal pterygiumLavinia La Grasta SabolićAna KovačevićLucija Ana TrtanjBernardica Valent MorićJasna TumbriClitoromegaly can be congenital or acquired, and it is usually associated with exposure to androgen excess. Pathophysiological mechanisms responsible for transient clitoromegaly in premature female infants have not been fully elucidated. Herein, we present the case of an extremely premature female twin infant, with an extensive web of skin on the back of the left leg, hypoplastic left labia majora, and normal clitoris appearance at birth. At the age of 48 days, clitoral enlargement was observed. Significantly elevated levels of gonadotropins, testosterone, and dehydroepiandrosterone sulphate (DHEAS) were recorded. 17-hydroxyprogesterone (17OHP) was unremarkable, and anti-Müllerian hormone (AMH) was low, in accordance with normal female karyotype. Ovaries were not visualised ultrasonographically. During the following weeks, gradual normalisation of gonadotropin, testosterone, and DHEAS levels was accompanied by regression of clitoromegaly. As described in this case, transient clitoral enlargement may appear in extremely premature female infants due to transitory elevated androgens of ovarian and adrenal origin.https://www.termedia.pl/Transient-clitoromegaly-in-an-extremely-preterm-twin-infant-with-popliteal-r-npterygium,138,54678,1,1.htmlpreterm neonate transient clitoromegaly popliteal pterygium. |
| spellingShingle | Lavinia La Grasta Sabolić Ana Kovačević Lucija Ana Trtanj Bernardica Valent Morić Jasna Tumbri Transient clitoromegaly in an extremely preterm twin infant with popliteal pterygium Pediatric Endocrinology, Diabetes and Metabolism preterm neonate transient clitoromegaly popliteal pterygium. |
| title | Transient clitoromegaly in an extremely preterm twin infant with popliteal
pterygium |
| title_full | Transient clitoromegaly in an extremely preterm twin infant with popliteal
pterygium |
| title_fullStr | Transient clitoromegaly in an extremely preterm twin infant with popliteal
pterygium |
| title_full_unstemmed | Transient clitoromegaly in an extremely preterm twin infant with popliteal
pterygium |
| title_short | Transient clitoromegaly in an extremely preterm twin infant with popliteal
pterygium |
| title_sort | transient clitoromegaly in an extremely preterm twin infant with popliteal pterygium |
| topic | preterm neonate transient clitoromegaly popliteal pterygium. |
| url | https://www.termedia.pl/Transient-clitoromegaly-in-an-extremely-preterm-twin-infant-with-popliteal-r-npterygium,138,54678,1,1.html |
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