Coordination compounds cobalt bis(citrate)stannate - are results of searching new antiinfluenza drugs
The pharmacological properties of new coordination compound - the biologically active substance - cobalt bis(citrate) stannate was studied. The result of researching are: the compound has antiviral activity against human influenza virus strains A/ Honghong/1/68 (H3N2), A/PR/8/34 (H1N1), and influenz...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2014-04-01
|
| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/142 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The pharmacological properties of new coordination compound - the biologically active substance - cobalt bis(citrate) stannate was studied. The result of researching are: the compound has antiviral activity against human influenza virus strains A/ Honghong/1/68 (H3N2), A/PR/8/34 (H1N1), and influenza virus H5N3 in tissue culture chorio-allantoic membranes (CAM) of chick embryos 11-12 daily and monolayer culture of MDCK cells used. Compound has a low toxicity (by intraperitoneal injection LD50 = 206,63 mg/kg; orally - LD50 = 1836,76), that gives perspective to further his preclinical studies as an antiviral agent. |
|---|---|
| ISSN: | 2587-7836 2686-8830 |