Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration
The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between c...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2024/6614044 |
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| author | Mihaela Maria Budiul Gabriela Vlase Daniel Negru Dorinel Okolišan Ionela-Amalia Bradu Alexandra Tăşală Alexandru Pahomi Titus Vlase Daniela Jumanca Atena Galuscan Paula Sfirloaga Nicoleta Carabă Roxana Popescu Anamaria Matichescu |
| author_facet | Mihaela Maria Budiul Gabriela Vlase Daniel Negru Dorinel Okolišan Ionela-Amalia Bradu Alexandra Tăşală Alexandru Pahomi Titus Vlase Daniela Jumanca Atena Galuscan Paula Sfirloaga Nicoleta Carabă Roxana Popescu Anamaria Matichescu |
| author_sort | Mihaela Maria Budiul |
| collection | DOAJ |
| description | The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers such as chitosan, alginate, and kappa-carrageenan have been shown to be optimal materials for drug delivery due to their intrinsic biocompatibility. Binary, ternary, and quaternary mixtures between components are analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. According to the FTIR, thermogravimetry, UV-Vis, SEM, and cytotoxicity tests performed in this study, it can be said that it is quite easy to obtain materials that can be used in dental practice that facilitate bone reconstruction through local treatment. At the same time, it was found that both active substances can be incorporated into the material together with Alg and Chit, thus limiting the adverse effects and maximizing the local beneficial effects. |
| format | Article |
| id | doaj-art-bfe90791a2a84b35824b8222cc44d8cb |
| institution | OA Journals |
| issn | 2090-9071 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-bfe90791a2a84b35824b8222cc44d8cb2025-08-20T02:19:27ZengWileyJournal of Chemistry2090-90712024-01-01202410.1155/2024/6614044Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue RegenerationMihaela Maria Budiul0Gabriela Vlase1Daniel Negru2Dorinel Okolišan3Ionela-Amalia Bradu4Alexandra Tăşală5Alexandru Pahomi6Titus Vlase7Daniela Jumanca8Atena Galuscan9Paula Sfirloaga10Nicoleta Carabă11Roxana Popescu12Anamaria Matichescu13Research Centre for Thermal Analysis in Environmental Problems- ICAMResearch Centre for Thermal Analysis in Environmental Problems- ICAMUniversity of Medicine and Pharmacy “Victor Babes”Research Centre for Thermal Analysis in Environmental Problems- ICAMResearch Centre for Thermal Analysis in Environmental Problems- ICAMResearch Centre for Thermal Analysis in Environmental Problems- ICAMResearch Centre for Thermal Analysis in Environmental Problems- ICAMResearch Centre for Thermal Analysis in Environmental Problems- ICAMUniversity of Medicine and Pharmacy “Victor Babes”University of Medicine and Pharmacy “Victor Babes”National Institute for Research and Development in Electrochemistry and Condensed MatterWest University of TimisoaraFaculty of MedicineUniversity of Medicine and Pharmacy “Victor Babes”The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers such as chitosan, alginate, and kappa-carrageenan have been shown to be optimal materials for drug delivery due to their intrinsic biocompatibility. Binary, ternary, and quaternary mixtures between components are analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. According to the FTIR, thermogravimetry, UV-Vis, SEM, and cytotoxicity tests performed in this study, it can be said that it is quite easy to obtain materials that can be used in dental practice that facilitate bone reconstruction through local treatment. At the same time, it was found that both active substances can be incorporated into the material together with Alg and Chit, thus limiting the adverse effects and maximizing the local beneficial effects.http://dx.doi.org/10.1155/2024/6614044 |
| spellingShingle | Mihaela Maria Budiul Gabriela Vlase Daniel Negru Dorinel Okolišan Ionela-Amalia Bradu Alexandra Tăşală Alexandru Pahomi Titus Vlase Daniela Jumanca Atena Galuscan Paula Sfirloaga Nicoleta Carabă Roxana Popescu Anamaria Matichescu Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration Journal of Chemistry |
| title | Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration |
| title_full | Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration |
| title_fullStr | Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration |
| title_full_unstemmed | Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration |
| title_short | Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration |
| title_sort | dental biopolymer composites with antibiotics bisphosphonate and hydroxyapatite for possible use in bone tissue regeneration |
| url | http://dx.doi.org/10.1155/2024/6614044 |
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