Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1

Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1

Abstract Background A close relationship exists between castration-resistant prostate cancer (CRPC) and histidine metabolism by gut microbes. However, the effects of the histidine metabolite imidazole propionate (IMP) on prostate cancer (PCa) and its underlying mechanisms are not well understood. Me...

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Bibliographic Details
Main Authors: Shengkai Jin, Yuhua Zhou, Jing Lv, Yichen Lu, Yuwei Zhang, Menglu Li, Ninghan Feng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
Imidazole propionate
Histidine
Prostate cancer
Microbiome
Castration-resistant prostate cancer
Online Access:https://doi.org/10.1186/s10020-025-01073-0
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