Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient
Pheochromocytomas (PCCs) are rare neuroendocrine tumors originating from the adrenal medulla, particularly uncommon in pediatric populations. This case report presents a 12-year-old boy with a three-year history of fatigue and a one-year history of blurred vision, who was admitted with severe hypert...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1439186/full |
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| author | Shenghua Yu Tianxiao Zou Sisi Wei Yani Yu Guili Ding |
| author_facet | Shenghua Yu Tianxiao Zou Sisi Wei Yani Yu Guili Ding |
| author_sort | Shenghua Yu |
| collection | DOAJ |
| description | Pheochromocytomas (PCCs) are rare neuroendocrine tumors originating from the adrenal medulla, particularly uncommon in pediatric populations. This case report presents a 12-year-old boy with a three-year history of fatigue and a one-year history of blurred vision, who was admitted with severe hypertension (230/200 mmHg). Abdominal CT imaging revealed bilateral adrenal masses measuring 40 mm on the left and 12 mm on the right. The diagnosis of pheochromocytoma was confirmed by elevated blood catecholamine metabolites. During perioperative preparation, the patient experienced complications, including polyuria, thrombosis, and infection, necessitating an emergency resection of the right adrenal tumor. This intervention led to a successful recovery. Subsequent genetic testing identified a mutation in the VHL gene. After further medical management, the left adrenal tumor was also successfully removed. At one-year follow-up, the patient remained normotensive with no signs of recurrence. This case emphasizes the critical role of genetic testing and cutious perioperative management in the treatment of pediatric pheochromocytoma. |
| format | Article |
| id | doaj-art-bfd9483f0fd04631968811843bf31e24 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-bfd9483f0fd04631968811843bf31e242025-02-11T06:59:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.14391861439186Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patientShenghua Yu0Tianxiao Zou1Sisi Wei2Yani Yu3Guili Ding4Department of Anesthesiology, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of SICU, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of SICU, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of SICU, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaPheochromocytomas (PCCs) are rare neuroendocrine tumors originating from the adrenal medulla, particularly uncommon in pediatric populations. This case report presents a 12-year-old boy with a three-year history of fatigue and a one-year history of blurred vision, who was admitted with severe hypertension (230/200 mmHg). Abdominal CT imaging revealed bilateral adrenal masses measuring 40 mm on the left and 12 mm on the right. The diagnosis of pheochromocytoma was confirmed by elevated blood catecholamine metabolites. During perioperative preparation, the patient experienced complications, including polyuria, thrombosis, and infection, necessitating an emergency resection of the right adrenal tumor. This intervention led to a successful recovery. Subsequent genetic testing identified a mutation in the VHL gene. After further medical management, the left adrenal tumor was also successfully removed. At one-year follow-up, the patient remained normotensive with no signs of recurrence. This case emphasizes the critical role of genetic testing and cutious perioperative management in the treatment of pediatric pheochromocytoma.https://www.frontiersin.org/articles/10.3389/fped.2025.1439186/fullpheochromocytomaparagangliomapediatric endocrinologyhypertensionperioperative management |
| spellingShingle | Shenghua Yu Tianxiao Zou Sisi Wei Yani Yu Guili Ding Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient Frontiers in Pediatrics pheochromocytoma paraganglioma pediatric endocrinology hypertension perioperative management |
| title | Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| title_full | Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| title_fullStr | Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| title_full_unstemmed | Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| title_short | Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| title_sort | comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient |
| topic | pheochromocytoma paraganglioma pediatric endocrinology hypertension perioperative management |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1439186/full |
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