Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers
Microemulsions are relatively stable carrier agents for bioactive components. This study aimed to determine the characteristics of oil-in-water (O/W) microemulsions as carriers of α-tocopherol compounds in variations of α-tocopherol concentration, pH, and dilution. The O/W microemulsion was made fro...
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National Centre of Excellence in Analytical Chemsitry
2025-06-01
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| Series: | Pakistan Journal of Analytical & Environmental Chemistry |
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| Online Access: | https://pjaec.pk/index.php/pjaec/article/view/12 |
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| author | I Dewa Gde Mayun Permana Lutfi Suhendra Bambang Admadi Harsojuwono Ida Bagus Wayan Gunam |
| author_facet | I Dewa Gde Mayun Permana Lutfi Suhendra Bambang Admadi Harsojuwono Ida Bagus Wayan Gunam |
| author_sort | I Dewa Gde Mayun Permana |
| collection | DOAJ |
| description | Microemulsions are relatively stable carrier agents for bioactive components. This study aimed to determine the characteristics of oil-in-water (O/W) microemulsions as carriers of α-tocopherol compounds in variations of α-tocopherol concentration, pH, and dilution. The O/W microemulsion was made from a mixture of surfactants (Tween 80, Tween 20, and Span 80) with virgin coconut oil (VCO) in a ratio of 85:15 with a total volume of 5 mL added with 10 mL of distilled water. The research used a randomized block design (RBD). The data were analyzed using ANOVA and
continued with Tukey's test and regression analysis. Treatments in microemulsion were the addition of α-tocopherol with concentrations of: 0.25, 1.50, 1.75 and 2.0%. Observations were made on the turbidity index values, appearance, droplet diameter, and microemulsion stability. In
addition, observations were made on the stability of the microemulsion at variations of pH (4.5,5.5, 6.5), and dilution (10, 50, and 100 times). The results showed that the microemulsion was able to carry α-tocopherol compounds up to a concentration of 2% with a turbidity value reaching
0.1036 ± 0.0033% with a transparent appearance. A mixture of three surfactants (Tween 80, Tween 20 and Span 80) has the ability to increase droplet stability. The α-tocopherol microemulsion had a droplet diameter below 30 nm and stayed stable against the effects of centrifugation at pH 4.5 with dilutions up to 50 times and remained stable upto pH 6.5 with
dilutions between 50 – 100 times. |
| format | Article |
| id | doaj-art-bfd8b9df4f544fd89dec6ef09ca8dde8 |
| institution | DOAJ |
| issn | 1996-918X 2221-5255 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | National Centre of Excellence in Analytical Chemsitry |
| record_format | Article |
| series | Pakistan Journal of Analytical & Environmental Chemistry |
| spelling | doaj-art-bfd8b9df4f544fd89dec6ef09ca8dde82025-08-20T03:17:56ZengNational Centre of Excellence in Analytical ChemsitryPakistan Journal of Analytical & Environmental Chemistry1996-918X2221-52552025-06-01250112613410.21743/pjaec/2024.06.12Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol CarriersI Dewa Gde Mayun Permana 0Lutfi Suhendra 1Bambang Admadi Harsojuwono2Ida Bagus Wayan Gunam3Department of Food Science and Technology, Agriculture Technology Faculty, Udayana University, Badung (80361), Bali, IndonesiaDepartment of Agroindustry Technology, Agriculture Technology Faculty, Udayana University, Badung (80361), Bali, IndonesiaDepartment of Agroindustry Technology, Agriculture Technology Faculty, Udayana University, Badung (80361), Bali, IndonesiaDepartmentof Agroindustry Technology, Agriculture Technology Faculty, Udayana University, Badung (80361), Bali, Indonesia Microemulsions are relatively stable carrier agents for bioactive components. This study aimed to determine the characteristics of oil-in-water (O/W) microemulsions as carriers of α-tocopherol compounds in variations of α-tocopherol concentration, pH, and dilution. The O/W microemulsion was made from a mixture of surfactants (Tween 80, Tween 20, and Span 80) with virgin coconut oil (VCO) in a ratio of 85:15 with a total volume of 5 mL added with 10 mL of distilled water. The research used a randomized block design (RBD). The data were analyzed using ANOVA and continued with Tukey's test and regression analysis. Treatments in microemulsion were the addition of α-tocopherol with concentrations of: 0.25, 1.50, 1.75 and 2.0%. Observations were made on the turbidity index values, appearance, droplet diameter, and microemulsion stability. In addition, observations were made on the stability of the microemulsion at variations of pH (4.5,5.5, 6.5), and dilution (10, 50, and 100 times). The results showed that the microemulsion was able to carry α-tocopherol compounds up to a concentration of 2% with a turbidity value reaching 0.1036 ± 0.0033% with a transparent appearance. A mixture of three surfactants (Tween 80, Tween 20 and Span 80) has the ability to increase droplet stability. The α-tocopherol microemulsion had a droplet diameter below 30 nm and stayed stable against the effects of centrifugation at pH 4.5 with dilutions up to 50 times and remained stable upto pH 6.5 with dilutions between 50 – 100 times.https://pjaec.pk/index.php/pjaec/article/view/12microemulsion characteristicsconcentration of α-tocopherolsurfactant |
| spellingShingle | I Dewa Gde Mayun Permana Lutfi Suhendra Bambang Admadi Harsojuwono Ida Bagus Wayan Gunam Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers Pakistan Journal of Analytical & Environmental Chemistry microemulsion characteristics concentration of α-tocopherol surfactant |
| title | Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers |
| title_full | Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers |
| title_fullStr | Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers |
| title_full_unstemmed | Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers |
| title_short | Microemulsion Characteristics of Oil-in-Water with Surfactants as α-tocopherol Carriers |
| title_sort | microemulsion characteristics of oil in water with surfactants as α tocopherol carriers |
| topic | microemulsion characteristics concentration of α-tocopherol surfactant |
| url | https://pjaec.pk/index.php/pjaec/article/view/12 |
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