Biological sex impacts COVID-19 outcomes.
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. W...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-06-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008570&type=printable |
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| _version_ | 1850239955945652224 |
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| author | Sabra L Klein Santosh Dhakal Rebecca L Ursin Sharvari Deshpande Kathryn Sandberg Franck Mauvais-Jarvis |
| author_facet | Sabra L Klein Santosh Dhakal Rebecca L Ursin Sharvari Deshpande Kathryn Sandberg Franck Mauvais-Jarvis |
| author_sort | Sabra L Klein |
| collection | DOAJ |
| description | The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19. |
| format | Article |
| id | doaj-art-bfd6867c3bff42e687374501c5eb4c8b |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-bfd6867c3bff42e687374501c5eb4c8b2025-08-20T02:01:00ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742020-06-01166e100857010.1371/journal.ppat.1008570Biological sex impacts COVID-19 outcomes.Sabra L KleinSantosh DhakalRebecca L UrsinSharvari DeshpandeKathryn SandbergFranck Mauvais-JarvisThe current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008570&type=printable |
| spellingShingle | Sabra L Klein Santosh Dhakal Rebecca L Ursin Sharvari Deshpande Kathryn Sandberg Franck Mauvais-Jarvis Biological sex impacts COVID-19 outcomes. PLoS Pathogens |
| title | Biological sex impacts COVID-19 outcomes. |
| title_full | Biological sex impacts COVID-19 outcomes. |
| title_fullStr | Biological sex impacts COVID-19 outcomes. |
| title_full_unstemmed | Biological sex impacts COVID-19 outcomes. |
| title_short | Biological sex impacts COVID-19 outcomes. |
| title_sort | biological sex impacts covid 19 outcomes |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008570&type=printable |
| work_keys_str_mv | AT sabralklein biologicalseximpactscovid19outcomes AT santoshdhakal biologicalseximpactscovid19outcomes AT rebeccalursin biologicalseximpactscovid19outcomes AT sharvarideshpande biologicalseximpactscovid19outcomes AT kathrynsandberg biologicalseximpactscovid19outcomes AT franckmauvaisjarvis biologicalseximpactscovid19outcomes |