Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide
Ethnopharmacological relevanceCodonopsis pilosula (Franch.) Nannf. (CP) is one of the most popular Qi-invigorating herbal medicines and has been extensively used to promote health and vitality in China for a long time. Codonopsis pilosula (Franch.) Nannf. polysaccharide (CPP) is the principal active...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545356/full |
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| author | He Li He Li Letian Zhang Letian Zhang Xingtai Li Haocheng He Guoan Fu Yi Zhun Zhu Wei Hu Lige Qiu Liang Gong Youming Zhang Youming Zhang |
| author_facet | He Li He Li Letian Zhang Letian Zhang Xingtai Li Haocheng He Guoan Fu Yi Zhun Zhu Wei Hu Lige Qiu Liang Gong Youming Zhang Youming Zhang |
| author_sort | He Li |
| collection | DOAJ |
| description | Ethnopharmacological relevanceCodonopsis pilosula (Franch.) Nannf. (CP) is one of the most popular Qi-invigorating herbal medicines and has been extensively used to promote health and vitality in China for a long time. Codonopsis pilosula (Franch.) Nannf. polysaccharide (CPP) is the principal active components of CP, which is considered as the reason for CP widespread application. However, it has not been revealed that CPP exert a Qi-invigoration effect by protecting mitochondria and/or improving mitochondrial function in the existing traditional Chinese medicine theories.Aim of the studyWe extracted CPP from C. pilosula and investigated the effects of CPP on energy metabolism and mitochondrial protection.MethodsBased on the mice chronic hypoxia model for imitating the energy deficiency state of the human body, which was administered with CPP by oral gavage daily for 10 days, mitochondrial permeability transition (MPT), lipid peroxidation product malondialdehyde (MDA) in brain, mitochondrial respiratory function, the levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) in liver cells were assayed. Adenylate energy charge (AEC), total adenylate pool (TAP), ATP/ADP, and ATP/AMP ratios were calculated.ResultsCPP can inhibit the formation of MDA in mice brains, decrease oxygen consuming rate and respiratory control ratio (RCR) of liver mitochondria, increase levels of ATP, TAP and AEC in liver cells under chronic hypoxia condition.ConclusionCPP can possess and improve mitochondrial energy metabolism and bioenergetic levels. |
| format | Article |
| id | doaj-art-bfd52d99cad64859b0f7fcb42743bbd2 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bfd52d99cad64859b0f7fcb42743bbd22025-08-20T03:17:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15453561545356Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharideHe Li0He Li1Letian Zhang2Letian Zhang3Xingtai Li4Haocheng He5Guoan Fu6Yi Zhun Zhu7Wei Hu8Lige Qiu9Liang Gong10Youming Zhang11Youming Zhang12School of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaCollege of Life Science, Dalian Minzu University, Dalian, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, ChinaEthnopharmacological relevanceCodonopsis pilosula (Franch.) Nannf. (CP) is one of the most popular Qi-invigorating herbal medicines and has been extensively used to promote health and vitality in China for a long time. Codonopsis pilosula (Franch.) Nannf. polysaccharide (CPP) is the principal active components of CP, which is considered as the reason for CP widespread application. However, it has not been revealed that CPP exert a Qi-invigoration effect by protecting mitochondria and/or improving mitochondrial function in the existing traditional Chinese medicine theories.Aim of the studyWe extracted CPP from C. pilosula and investigated the effects of CPP on energy metabolism and mitochondrial protection.MethodsBased on the mice chronic hypoxia model for imitating the energy deficiency state of the human body, which was administered with CPP by oral gavage daily for 10 days, mitochondrial permeability transition (MPT), lipid peroxidation product malondialdehyde (MDA) in brain, mitochondrial respiratory function, the levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) in liver cells were assayed. Adenylate energy charge (AEC), total adenylate pool (TAP), ATP/ADP, and ATP/AMP ratios were calculated.ResultsCPP can inhibit the formation of MDA in mice brains, decrease oxygen consuming rate and respiratory control ratio (RCR) of liver mitochondria, increase levels of ATP, TAP and AEC in liver cells under chronic hypoxia condition.ConclusionCPP can possess and improve mitochondrial energy metabolism and bioenergetic levels.https://www.frontiersin.org/articles/10.3389/fphar.2025.1545356/fullCodonopsis pilosula (Franch.) Nannf. polysaccharidemitochondriaenergy metabolismmitochondrial respiratory functionanti-hypoxiaadenosine triphosphate |
| spellingShingle | He Li He Li Letian Zhang Letian Zhang Xingtai Li Haocheng He Guoan Fu Yi Zhun Zhu Wei Hu Lige Qiu Liang Gong Youming Zhang Youming Zhang Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide Frontiers in Pharmacology Codonopsis pilosula (Franch.) Nannf. polysaccharide mitochondria energy metabolism mitochondrial respiratory function anti-hypoxia adenosine triphosphate |
| title | Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide |
| title_full | Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide |
| title_fullStr | Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide |
| title_full_unstemmed | Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide |
| title_short | Improvement on mitochondrial energy metabolism of Codonopsis pilosula (Franch.) Nannf. polysaccharide |
| title_sort | improvement on mitochondrial energy metabolism of codonopsis pilosula franch nannf polysaccharide |
| topic | Codonopsis pilosula (Franch.) Nannf. polysaccharide mitochondria energy metabolism mitochondrial respiratory function anti-hypoxia adenosine triphosphate |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545356/full |
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