Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn
Introduction. Melioidosis is a bacterial infection caused by a Gram-negative bacillus Burkholderia pseudomallei, prevalent in Southeast Asia and Northern Australia. Sri Lanka is situated in the endemic belt of melioidosis. Melioidosis has a wide spectrum of clinical presentations and results in high...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/5563214 |
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| author | Dinuka S Warapitiya Shyama Subasinghe Rukshanie Frances de Silva Dadallage Lalitha Piyarisi Kushlani Jayatilleke |
| author_facet | Dinuka S Warapitiya Shyama Subasinghe Rukshanie Frances de Silva Dadallage Lalitha Piyarisi Kushlani Jayatilleke |
| author_sort | Dinuka S Warapitiya |
| collection | DOAJ |
| description | Introduction. Melioidosis is a bacterial infection caused by a Gram-negative bacillus Burkholderia pseudomallei, prevalent in Southeast Asia and Northern Australia. Sri Lanka is situated in the endemic belt of melioidosis. Melioidosis has a wide spectrum of clinical presentations and results in high mortality rates in severe infection. Case Report. We report a 54-year-old previously healthy Sri Lankan farmer who presented with septicemia following a cut injury to the right leg while working in a paddy field. Initially, he had mild wound sepsis, and later, his condition deteriorated rapidly. The patient required organ support later for cardiovascular instability, acute liver failure, acute kidney injury, acute respiratory distress syndrome, and coagulopathy. The patient’s blood culture was negative on the admission day, and the repeated blood culture taken at the ICU was contaminated with a commensal flora initially and later isolated Burkholderia pseudomallei. Although wound swab culture taken on the first day isolated an organism, it took six days to identify it as Burkholderia pseudomallei. The patient succumbed to severe melioidosis leading to a severe sepsis and multiorgan failure in spite of treatment with meropenem. Conclusion. This case report highlights the importance of considering melioidosis as a differential diagnosis when a patient comes with risk factors for melioidosis. |
| format | Article |
| id | doaj-art-bfd5060dacc441e1809128cc5ca69c6b |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-bfd5060dacc441e1809128cc5ca69c6b2025-08-20T03:22:38ZengWileyCase Reports in Medicine1687-96271687-96352021-01-01202110.1155/2021/55632145563214Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to LearnDinuka S Warapitiya0Shyama Subasinghe1Rukshanie Frances de Silva2Dadallage Lalitha Piyarisi3Kushlani Jayatilleke4Post Graduate Institute of Medicine, University of Colombo, Colombo, Sri LankaSri Jayewardenepura General Hospital, Nugegoda, Colombo, Sri LankaPost Graduate Institute of Medicine, University of Colombo, Colombo, Sri LankaSri Jayewardenepura General Hospital, Nugegoda, Colombo, Sri LankaSri Jayewardenepura General Hospital, Nugegoda, Colombo, Sri LankaIntroduction. Melioidosis is a bacterial infection caused by a Gram-negative bacillus Burkholderia pseudomallei, prevalent in Southeast Asia and Northern Australia. Sri Lanka is situated in the endemic belt of melioidosis. Melioidosis has a wide spectrum of clinical presentations and results in high mortality rates in severe infection. Case Report. We report a 54-year-old previously healthy Sri Lankan farmer who presented with septicemia following a cut injury to the right leg while working in a paddy field. Initially, he had mild wound sepsis, and later, his condition deteriorated rapidly. The patient required organ support later for cardiovascular instability, acute liver failure, acute kidney injury, acute respiratory distress syndrome, and coagulopathy. The patient’s blood culture was negative on the admission day, and the repeated blood culture taken at the ICU was contaminated with a commensal flora initially and later isolated Burkholderia pseudomallei. Although wound swab culture taken on the first day isolated an organism, it took six days to identify it as Burkholderia pseudomallei. The patient succumbed to severe melioidosis leading to a severe sepsis and multiorgan failure in spite of treatment with meropenem. Conclusion. This case report highlights the importance of considering melioidosis as a differential diagnosis when a patient comes with risk factors for melioidosis.http://dx.doi.org/10.1155/2021/5563214 |
| spellingShingle | Dinuka S Warapitiya Shyama Subasinghe Rukshanie Frances de Silva Dadallage Lalitha Piyarisi Kushlani Jayatilleke Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn Case Reports in Medicine |
| title | Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn |
| title_full | Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn |
| title_fullStr | Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn |
| title_full_unstemmed | Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn |
| title_short | Severe Sepsis with Multiorgan Failure due to Melioidosis: A Lesson to Learn |
| title_sort | severe sepsis with multiorgan failure due to melioidosis a lesson to learn |
| url | http://dx.doi.org/10.1155/2021/5563214 |
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