Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry
Background The role of age in the short‐ and long‐term prognosis of takotsubo syndrome (TTS) is controversial. The aim of the present study was to evaluate age‐related differences and prognostic implications among patients with TTS. Methods and Results In total, 2492 consecutive patients with TTS en...
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2024-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.030623 |
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| author | Ibrahim El‐Battrawy Francesco Santoro Iván J. Núñez‐Gil Toni Pätz Luca Arcari Mohammad Abumayyaleh Federico Guerra Giuseppina Novo Beatrice Musumeci Luca Cacciotti Enrica Mariano Pasquale Caldarola Giuseppe Parisi Roberta Montisci Enrica Vitale Massimo Volpe Miguel Corbì‐Pasqual Manuel Martinez‐Selles Manuel Almendro‐Delia Alessandro Sionis Aitor Uribarri Holger Thiele Natale Daniele Brunetti Ingo Eitel Ibrahim Akin Thomas Stiermaier |
| author_facet | Ibrahim El‐Battrawy Francesco Santoro Iván J. Núñez‐Gil Toni Pätz Luca Arcari Mohammad Abumayyaleh Federico Guerra Giuseppina Novo Beatrice Musumeci Luca Cacciotti Enrica Mariano Pasquale Caldarola Giuseppe Parisi Roberta Montisci Enrica Vitale Massimo Volpe Miguel Corbì‐Pasqual Manuel Martinez‐Selles Manuel Almendro‐Delia Alessandro Sionis Aitor Uribarri Holger Thiele Natale Daniele Brunetti Ingo Eitel Ibrahim Akin Thomas Stiermaier |
| author_sort | Ibrahim El‐Battrawy |
| collection | DOAJ |
| description | Background The role of age in the short‐ and long‐term prognosis of takotsubo syndrome (TTS) is controversial. The aim of the present study was to evaluate age‐related differences and prognostic implications among patients with TTS. Methods and Results In total, 2492 consecutive patients with TTS enrolled in an international registry were stratified into 4 groups (<45, 45–64, 65–74, and ≥75 years). The median long‐term follow‐up was 480 days (interquartile range, 83–1510 days). The primary outcome was all‐cause mortality (in‐hospital and out‐of‐hospital mortality). The secondary end point was TTS‐related in‐hospital complications. Among the 2479 patients, 58 (2.3%) were aged <45 years, 625 (25.1%) were aged 45 to 64 years, 733 (29.4%) were aged 65 to 74 years, and 1063 (42.6%) were aged ≥75 years. Young patients (<45 years) had a higher prevalence of men (from youngest to oldest, 24.1% versus 12.6% versus 9.7% versus 11.4%; P<0.01), physical triggers (46.6% versus 27.5%, 33.9%, and 38.4%; P<0.01), and non‐apical forms of TTS (25.9% versus 23.7%, 12.7%, and 9%; P<0.01) than those aged 45 to 64, 65 to 74, and ≥75 years. During hospitalization, young patients experienced a higher rate of in‐hospital complications (32.8% versus 23.4%, 27.4%, and 31.9%; P=0.01), but in‐hospital mortality was higher in the older group (0%, 1.6%, 2.9%, and 5%; P=0.001). Long‐term all‐cause mortality was significantly higher in the older cohort (5.6%, 6.4%, 11.3%, and 22.3%; log‐rank P<0.001), as was long‐term cardiovascular mortality (0%, 0.9%, 1.9%, and 3.2%; log‐rank P=0.01). Conclusions Young patients with TTS have a typical phenotype characterized by a higher prevalence of male sex, non‐apical ballooning patterns, and in‐hospital complications. However, in‐hospital and long‐term mortality are significantly lower in young patients with TTS. Registration URL: https://classic.clinicaltrials.gov/ct2/show/NCT04361994. Unique identifier: NCT04361994. |
| format | Article |
| id | doaj-art-bfd368b6e863438d8c4e4e9b83f86502 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-bfd368b6e863438d8c4e4e9b83f865022025-08-20T02:26:40ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-02-0113410.1161/JAHA.123.030623Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST RegistryIbrahim El‐Battrawy0Francesco Santoro1Iván J. Núñez‐Gil2Toni Pätz3Luca Arcari4Mohammad Abumayyaleh5Federico Guerra6Giuseppina Novo7Beatrice Musumeci8Luca Cacciotti9Enrica Mariano10Pasquale Caldarola11Giuseppe Parisi12Roberta Montisci13Enrica Vitale14Massimo Volpe15Miguel Corbì‐Pasqual16Manuel Martinez‐Selles17Manuel Almendro‐Delia18Alessandro Sionis19Aitor Uribarri20Holger Thiele21Natale Daniele Brunetti22Ingo Eitel23Ibrahim Akin24Thomas Stiermaier25Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology Ruhr University Bochum, Bochum, Germany Bochum GermanyDepartment of Medical and Surgical Sciences University of Foggia Foggia ItalyInterventional, Cardiology Cardiovascular Institute, Hospital Clínico Universitario San Carlos Madrid SpainMedical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck University Heart Center Lübeck Lübeck GermanyInstitute of Cardiology Madre Giuseppina Vannini Hospital Rome ItalyInstitute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology Ruhr University Bochum, Bochum, Germany Bochum GermanyCardiology and Arrhythmology Clinic Marche Polytechnic University, University Hospital “Umberto I—Lancisi—Salesi” Ancona ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Cardiology Unit University of Palermo, University Hospital P. Giaccone Palermo ItalyCardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology Sapienza University of Rome Rome ItalyCardiology Unit Madre Giuseppina Vannini Hospital Rome ItalyDivision of Cardiology University of Rome Tor Vergata Rome ItalyDepartment of Cardiology San Paolo Hospital Bari ItalyPediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital University of Catania Catania ItalyClinical Cardiology, Department of Medical Science and Public Health University of Cagliari Cagliari ItalyDepartment of Medical and Surgical Sciences University of Foggia Foggia ItalyCardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology Sapienza University of Rome Rome ItalyDepartment of Cardiology Complejo Hospitalario de Albacete Albacete SpainDepartment of Cardiology Hospital General Universitario Gregorio Marañon, Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares Madrid SpainServicio de Cardiología Hospital Virgen de la Macarena Sevilla SpainUnidad de Cuidados Intensivos Cardiológicos, Servicio de Cardiología, Hospital de Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau) Barcelona SpainCardiology Service, Vall d’Hebron University Hospital Barcelona SpainDepartment of Internal Medicine/Cardiology Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute Leipzig GermanyDepartment of Medical and Surgical Sciences University of Foggia Foggia ItalyMedical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck University Heart Center Lübeck Lübeck GermanyUniversity of Mannheim Mannheim GermanyMedical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck University Heart Center Lübeck Lübeck GermanyBackground The role of age in the short‐ and long‐term prognosis of takotsubo syndrome (TTS) is controversial. The aim of the present study was to evaluate age‐related differences and prognostic implications among patients with TTS. Methods and Results In total, 2492 consecutive patients with TTS enrolled in an international registry were stratified into 4 groups (<45, 45–64, 65–74, and ≥75 years). The median long‐term follow‐up was 480 days (interquartile range, 83–1510 days). The primary outcome was all‐cause mortality (in‐hospital and out‐of‐hospital mortality). The secondary end point was TTS‐related in‐hospital complications. Among the 2479 patients, 58 (2.3%) were aged <45 years, 625 (25.1%) were aged 45 to 64 years, 733 (29.4%) were aged 65 to 74 years, and 1063 (42.6%) were aged ≥75 years. Young patients (<45 years) had a higher prevalence of men (from youngest to oldest, 24.1% versus 12.6% versus 9.7% versus 11.4%; P<0.01), physical triggers (46.6% versus 27.5%, 33.9%, and 38.4%; P<0.01), and non‐apical forms of TTS (25.9% versus 23.7%, 12.7%, and 9%; P<0.01) than those aged 45 to 64, 65 to 74, and ≥75 years. During hospitalization, young patients experienced a higher rate of in‐hospital complications (32.8% versus 23.4%, 27.4%, and 31.9%; P=0.01), but in‐hospital mortality was higher in the older group (0%, 1.6%, 2.9%, and 5%; P=0.001). Long‐term all‐cause mortality was significantly higher in the older cohort (5.6%, 6.4%, 11.3%, and 22.3%; log‐rank P<0.001), as was long‐term cardiovascular mortality (0%, 0.9%, 1.9%, and 3.2%; log‐rank P=0.01). Conclusions Young patients with TTS have a typical phenotype characterized by a higher prevalence of male sex, non‐apical ballooning patterns, and in‐hospital complications. However, in‐hospital and long‐term mortality are significantly lower in young patients with TTS. Registration URL: https://classic.clinicaltrials.gov/ct2/show/NCT04361994. Unique identifier: NCT04361994.https://www.ahajournals.org/doi/10.1161/JAHA.123.030623age variationshort‐ and long‐term outcometakotsubo syndrome |
| spellingShingle | Ibrahim El‐Battrawy Francesco Santoro Iván J. Núñez‐Gil Toni Pätz Luca Arcari Mohammad Abumayyaleh Federico Guerra Giuseppina Novo Beatrice Musumeci Luca Cacciotti Enrica Mariano Pasquale Caldarola Giuseppe Parisi Roberta Montisci Enrica Vitale Massimo Volpe Miguel Corbì‐Pasqual Manuel Martinez‐Selles Manuel Almendro‐Delia Alessandro Sionis Aitor Uribarri Holger Thiele Natale Daniele Brunetti Ingo Eitel Ibrahim Akin Thomas Stiermaier Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease age variation short‐ and long‐term outcome takotsubo syndrome |
| title | Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry |
| title_full | Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry |
| title_fullStr | Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry |
| title_full_unstemmed | Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry |
| title_short | Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry |
| title_sort | age related differences in takotsubo syndrome results from the multicenter geist registry |
| topic | age variation short‐ and long‐term outcome takotsubo syndrome |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.030623 |
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