Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications
This study investigates the synthesis, characterization, and antimicrobial properties of hydrogels synthesized through the UV-pulsed laser photopolymerization of a polymer–photoinitiator–chlorpromazine mixture. Chlorpromazine was used for its known enhanced antimicrobial properties when exposed to U...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/10/632 |
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| author | Tatiana Tozar Simona Nistorescu Gratiela Gradisteanu Pircalabioru Mihai Boni Angela Staicu |
| author_facet | Tatiana Tozar Simona Nistorescu Gratiela Gradisteanu Pircalabioru Mihai Boni Angela Staicu |
| author_sort | Tatiana Tozar |
| collection | DOAJ |
| description | This study investigates the synthesis, characterization, and antimicrobial properties of hydrogels synthesized through the UV-pulsed laser photopolymerization of a polymer–photoinitiator–chlorpromazine mixture. Chlorpromazine was used for its known enhanced antimicrobial properties when exposed to UV laser radiation. The hydrogel was formed from a mixture containing 0.05% Irgacure 2959, 10% gelatin methacryloyl, and various concentrations of chlorpromazine (1, 2, and 4 mg/mL). Laser-induced fluorescence spectroscopy was employed to monitor the photoinduced changes of chlorpromazine and Irgacure 2959 during hydrogel formation, providing insight into the photodegradation dynamics. FTIR spectroscopy confirmed the incorporation of irradiated chlorpromazine within the hydrogel matrix, while the release profiles of chlorpromazine showed sustained release only in hydrogels containing 1 mg/mL of CPZ. The hydrogel showed significant antimicrobial activity against MRSA bacteria when compared to that of penicillin. These findings highlight the potential of CPZ loaded during the photopolymerization process into hydrogels as effective antimicrobial agents with sustained release properties, making them suitable for combating resistant bacterial strains. |
| format | Article |
| id | doaj-art-bfd29af27ca141c090bcdbff15992000 |
| institution | OA Journals |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-bfd29af27ca141c090bcdbff159920002025-08-20T02:11:15ZengMDPI AGGels2310-28612024-09-01101063210.3390/gels10100632Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial ApplicationsTatiana Tozar0Simona Nistorescu1Gratiela Gradisteanu Pircalabioru2Mihai Boni3Angela Staicu4Laser Department, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, Magurele, 077125 Ilfov, RomaniaLaser Department, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, Magurele, 077125 Ilfov, RomaniaResearch Institute of the University of Bucharest (ICUB), University of Bucharest, 050095 Bucharest, RomaniaLaser Department, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, Magurele, 077125 Ilfov, RomaniaLaser Department, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, Magurele, 077125 Ilfov, RomaniaThis study investigates the synthesis, characterization, and antimicrobial properties of hydrogels synthesized through the UV-pulsed laser photopolymerization of a polymer–photoinitiator–chlorpromazine mixture. Chlorpromazine was used for its known enhanced antimicrobial properties when exposed to UV laser radiation. The hydrogel was formed from a mixture containing 0.05% Irgacure 2959, 10% gelatin methacryloyl, and various concentrations of chlorpromazine (1, 2, and 4 mg/mL). Laser-induced fluorescence spectroscopy was employed to monitor the photoinduced changes of chlorpromazine and Irgacure 2959 during hydrogel formation, providing insight into the photodegradation dynamics. FTIR spectroscopy confirmed the incorporation of irradiated chlorpromazine within the hydrogel matrix, while the release profiles of chlorpromazine showed sustained release only in hydrogels containing 1 mg/mL of CPZ. The hydrogel showed significant antimicrobial activity against MRSA bacteria when compared to that of penicillin. These findings highlight the potential of CPZ loaded during the photopolymerization process into hydrogels as effective antimicrobial agents with sustained release properties, making them suitable for combating resistant bacterial strains.https://www.mdpi.com/2310-2861/10/10/632Irgacure 2959gelatin methacryloylchlorpromazinephotopolymerization |
| spellingShingle | Tatiana Tozar Simona Nistorescu Gratiela Gradisteanu Pircalabioru Mihai Boni Angela Staicu Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications Gels Irgacure 2959 gelatin methacryloyl chlorpromazine photopolymerization |
| title | Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications |
| title_full | Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications |
| title_fullStr | Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications |
| title_full_unstemmed | Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications |
| title_short | Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications |
| title_sort | photopolymerization of chlorpromazine loaded gelatin methacryloyl hydrogels characterization and antimicrobial applications |
| topic | Irgacure 2959 gelatin methacryloyl chlorpromazine photopolymerization |
| url | https://www.mdpi.com/2310-2861/10/10/632 |
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