Combined experimental and computational analysis of DNA damage signaling reveals context‐dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Combined experimental and computational analysis of DNA damage signaling reveals context‐dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Abstract Following DNA damage, cells display complex multi‐pathway signaling dynamics that connect cell‐cycle arrest and DNA repair in G1, S, or G2/M phase with phenotypic fate decisions made between survival, cell‐cycle re‐entry and proliferation, permanent cell‐cycle arrest, or cell death. How the...

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Bibliographic Details
Main Authors: Andrea R Tentner, Michael J Lee, Gerry J Ostheimer, Leona D Samson, Douglas A Lauffenburger, Michael B Yaffe
Format: Article
Language:English
Published: Springer Nature 2012-01-01
Series:Molecular Systems Biology
Subjects:
apoptosis
cell‐cycle checkpoint
DNA damage
Erk
signal transduction
Online Access:https://doi.org/10.1038/msb.2012.1
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https://doi.org/10.1038/msb.2012.1

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