Biocatalysis is widely regarded as a sustainable technology to innovate Active Pharmaceutical Ingredient (API) synthesis. Biotransformation is considered a unique technology in the drug manufacturing world to unlock synthetic routes to complex chiral motifs. Sanofi is accelerating the development of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2025-05-01
|
| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.395/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849247099868151808 |
|---|---|
| author | Rabion, Alain Panigada, Davide Roy, Sebastien Bigot, Antony Tedrow, Jason S. |
| author_facet | Rabion, Alain Panigada, Davide Roy, Sebastien Bigot, Antony Tedrow, Jason S. |
| author_sort | Rabion, Alain |
| collection | DOAJ |
| description | Biocatalysis is widely regarded as a sustainable technology to innovate Active Pharmaceutical Ingredient (API) synthesis. Biotransformation is considered a unique technology in the drug manufacturing world to unlock synthetic routes to complex chiral motifs. Sanofi is accelerating the development of strong mindset and efficient capabilities in biocatalysis to foster API delivery and promote greener solutions for its synthetic processes.In this article, we will describe how Sanofi is building its internal biocatalytic capabilities in order to address new challenges related to sustainability and the growing complexity of its portfolio. The outcomes of recent studies will be presented demonstrating the successful implementation of the biocatalysis technology across early and late-stage development of our pipeline assets. |
| format | Article |
| id | doaj-art-bfcda2aad7a7497a833c034884dfc342 |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-bfcda2aad7a7497a833c034884dfc3422025-08-20T03:58:18ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432025-05-0128G150752010.5802/crchim.39510.5802/crchim.395Rabion, Alain0Panigada, Davide1https://orcid.org/0000-0003-0287-8426Roy, Sebastien2Bigot, Antony3https://orcid.org/0000-0003-3320-3755Tedrow, Jason S.4https://orcid.org/0000-0002-5663-2360Sanofi’s Chemistry, Manufacturing and Control, 1 impasse des ateliers, 94400 Vitry-sur-Seine, FranceSanofi’s Chemistry, Manufacturing and Control, 1 impasse des ateliers, 94400 Vitry-sur-Seine, FranceSanofi’s Chemistry, Manufacturing and Control, 1 impasse des ateliers, 94400 Vitry-sur-Seine, FranceSanofi’s Chemistry, Manufacturing and Control, 1 impasse des ateliers, 94400 Vitry-sur-Seine, FranceSanofi’s Chemistry, Manufacturing and Control, 350 Water St, Cambridge (U.S.) Massachusetts 02141, USABiocatalysis is widely regarded as a sustainable technology to innovate Active Pharmaceutical Ingredient (API) synthesis. Biotransformation is considered a unique technology in the drug manufacturing world to unlock synthetic routes to complex chiral motifs. Sanofi is accelerating the development of strong mindset and efficient capabilities in biocatalysis to foster API delivery and promote greener solutions for its synthetic processes.In this article, we will describe how Sanofi is building its internal biocatalytic capabilities in order to address new challenges related to sustainability and the growing complexity of its portfolio. The outcomes of recent studies will be presented demonstrating the successful implementation of the biocatalysis technology across early and late-stage development of our pipeline assets.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.395/BiocatalysisTransaminaseKetoreductaseTetrahydrofuran derivativeChiralityGreen chemistryEnzyme evolution |
| spellingShingle | Rabion, Alain Panigada, Davide Roy, Sebastien Bigot, Antony Tedrow, Jason S. Comptes Rendus. Chimie Biocatalysis Transaminase Ketoreductase Tetrahydrofuran derivative Chirality Green chemistry Enzyme evolution |
| topic | Biocatalysis Transaminase Ketoreductase Tetrahydrofuran derivative Chirality Green chemistry Enzyme evolution |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.395/ |