Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies
Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/701704 |
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| _version_ | 1849686589491380224 |
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| author | Sabrina Donnou Claire Galand Valérie Touitou Catherine Sautès-Fridman Zsuzsanna Fabry Sylvain Fisson |
| author_facet | Sabrina Donnou Claire Galand Valérie Touitou Catherine Sautès-Fridman Zsuzsanna Fabry Sylvain Fisson |
| author_sort | Sabrina Donnou |
| collection | DOAJ |
| description | Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape mechanisms and design new therapies. Here, we summarize the cell lines and murine models used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies. These data allow us to understand the role of the immune system in the fight against tumors. Exploring the advantages and limitations of immunocompetent versus immunodeficient models improves our understanding of the molecular and cellular mechanisms of tumor genesis and development as well as the fundamental processes governing the interaction of tumors and their host tissues. We posit that these basic preclinical investigations will open up new and promising approaches to designing better therapies. |
| format | Article |
| id | doaj-art-bfccc246a19f4271969aae252ea1bfc8 |
| institution | DOAJ |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-bfccc246a19f4271969aae252ea1bfc82025-08-20T03:22:39ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/701704701704Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer TherapiesSabrina Donnou0Claire Galand1Valérie Touitou2Catherine Sautès-Fridman3Zsuzsanna Fabry4Sylvain Fisson5Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Équipe Microenvironnement Immunitaire des Tumeurs, Centre de Recherche des Cordeliers, 75006 Paris, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Équipe Microenvironnement Immunitaire des Tumeurs, Centre de Recherche des Cordeliers, 75006 Paris, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Équipe Microenvironnement Immunitaire des Tumeurs, Centre de Recherche des Cordeliers, 75006 Paris, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Équipe Microenvironnement Immunitaire des Tumeurs, Centre de Recherche des Cordeliers, 75006 Paris, FranceDepartment of Pathology, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USAInstitut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Équipe Microenvironnement Immunitaire des Tumeurs, Centre de Recherche des Cordeliers, 75006 Paris, FranceHuman B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape mechanisms and design new therapies. Here, we summarize the cell lines and murine models used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies. These data allow us to understand the role of the immune system in the fight against tumors. Exploring the advantages and limitations of immunocompetent versus immunodeficient models improves our understanding of the molecular and cellular mechanisms of tumor genesis and development as well as the fundamental processes governing the interaction of tumors and their host tissues. We posit that these basic preclinical investigations will open up new and promising approaches to designing better therapies.http://dx.doi.org/10.1155/2012/701704 |
| spellingShingle | Sabrina Donnou Claire Galand Valérie Touitou Catherine Sautès-Fridman Zsuzsanna Fabry Sylvain Fisson Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies Advances in Hematology |
| title | Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies |
| title_full | Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies |
| title_fullStr | Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies |
| title_full_unstemmed | Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies |
| title_short | Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies |
| title_sort | murine models of b cell lymphomas promising tools for designing cancer therapies |
| url | http://dx.doi.org/10.1155/2012/701704 |
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