Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography
Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/684832 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849763821520945152 |
|---|---|
| author | Tsung-Han Tsai Chao Zhou Hsiang-Chieh Lee Yuankai K. Tao Osman O. Ahsen Marisa Figueiredo Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo |
| author_facet | Tsung-Han Tsai Chao Zhou Hsiang-Chieh Lee Yuankai K. Tao Osman O. Ahsen Marisa Figueiredo Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo |
| author_sort | Tsung-Han Tsai |
| collection | DOAJ |
| description | Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 μm depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment. |
| format | Article |
| id | doaj-art-bfcbd8ddec5a4296a9f17578e530d608 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-bfcbd8ddec5a4296a9f17578e530d6082025-08-20T03:05:17ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/684832684832Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence TomographyTsung-Han Tsai0Chao Zhou1Hsiang-Chieh Lee2Yuankai K. Tao3Osman O. Ahsen4Marisa Figueiredo5Desmond C. Adler6Joseph M. Schmitt7Qin Huang8James G. Fujimoto9Hiroshi Mashimo10Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USAGastroenterology Section, VA Boston Healthcare System, Boston, MA 02130, USALightLab Imaging Inc.-St. Jude Medical Inc., Westford, MA 01886, USALightLab Imaging Inc.-St. Jude Medical Inc., Westford, MA 01886, USAGastroenterology Section, VA Boston Healthcare System, Boston, MA 02130, USADepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USAGastroenterology Section, VA Boston Healthcare System, Boston, MA 02130, USATwo main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 μm depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment.http://dx.doi.org/10.1155/2012/684832 |
| spellingShingle | Tsung-Han Tsai Chao Zhou Hsiang-Chieh Lee Yuankai K. Tao Osman O. Ahsen Marisa Figueiredo Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography Gastroenterology Research and Practice |
| title | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_full | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_fullStr | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_full_unstemmed | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_short | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_sort | comparison of tissue architectural changes between radiofrequency ablation and cryospray ablation in barrett s esophagus using endoscopic three dimensional optical coherence tomography |
| url | http://dx.doi.org/10.1155/2012/684832 |
| work_keys_str_mv | AT tsunghantsai comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT chaozhou comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT hsiangchiehlee comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT yuankaiktao comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT osmanoahsen comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT marisafigueiredo comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT desmondcadler comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT josephmschmitt comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT qinhuang comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT jamesgfujimoto comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography AT hiroshimashimo comparisonoftissuearchitecturalchangesbetweenradiofrequencyablationandcryosprayablationinbarrettsesophagususingendoscopicthreedimensionalopticalcoherencetomography |