Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial

Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial

Background and objectiveCombining natural compounds with conventional drugs is an emerging strategy to improve the management of type 2 diabetes and its precursor, prediabetes. While metformin effectively lowers blood glucose and improves insulin sensitivity, it may cause side effects or lose effica...

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Bibliographic Details
Main Authors: Thais Cesar, Maria Rita Oliveira, Valeria Sandrim, Adriana Mendes, Ricardo Bruder, Rogerio Oliveira, Katia Sivieri, Dragan Milenkovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Nutrition
Subjects:
citrus flavonoids
nutraceutical
metformin
GLP-1
inflammatory biomarkers
antioxidant status
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1639901/full
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