Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments
The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical str...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/374098 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546762344103936 |
|---|---|
| author | Michael P. Kahle Gregory J. Bix |
| author_facet | Michael P. Kahle Gregory J. Bix |
| author_sort | Michael P. Kahle |
| collection | DOAJ |
| description | The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. Specific points of interest discussed include the incorporation of human comorbid conditions and drugs, the benefits of defining a proposed mechanism of action, replication of results using multiple methods, using clinically relevant routes of administration and treatment time windows, and performing and reporting good experimental methods to reduce bias such as, as suggested by the updated STAIR recommendations, sample size calculations, randomization, allocation concealment, blinding, and appropriate inclusion/exclusion criteria. It is our hope that reviewing and revisiting these considerations will benefit researchers in their investigations of stroke therapies and increase the likelihood of translational success in the battle against stroke. |
| format | Article |
| id | doaj-art-bfba87cb4bd045f59178102e1bcdfcb0 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-bfba87cb4bd045f59178102e1bcdfcb02025-02-03T06:47:24ZengWileyStroke Research and Treatment2090-81052042-00562012-01-01201210.1155/2012/374098374098Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke TreatmentsMichael P. Kahle0Gregory J. Bix1Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M Health Science Center, Bryan, TX 77807, USASanders-Brown Center on Aging and Department of Anatomy and Neurobiology, University of Kentucky, 430 Sanders Brown Building 800 S. Limestone Street, Lexington, KY 40536, USAThe Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. Specific points of interest discussed include the incorporation of human comorbid conditions and drugs, the benefits of defining a proposed mechanism of action, replication of results using multiple methods, using clinically relevant routes of administration and treatment time windows, and performing and reporting good experimental methods to reduce bias such as, as suggested by the updated STAIR recommendations, sample size calculations, randomization, allocation concealment, blinding, and appropriate inclusion/exclusion criteria. It is our hope that reviewing and revisiting these considerations will benefit researchers in their investigations of stroke therapies and increase the likelihood of translational success in the battle against stroke.http://dx.doi.org/10.1155/2012/374098 |
| spellingShingle | Michael P. Kahle Gregory J. Bix Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments Stroke Research and Treatment |
| title | Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments |
| title_full | Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments |
| title_fullStr | Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments |
| title_full_unstemmed | Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments |
| title_short | Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments |
| title_sort | successfully climbing the stairs surmounting failed translation of experimental ischemic stroke treatments |
| url | http://dx.doi.org/10.1155/2012/374098 |
| work_keys_str_mv | AT michaelpkahle successfullyclimbingthestairssurmountingfailedtranslationofexperimentalischemicstroketreatments AT gregoryjbix successfullyclimbingthestairssurmountingfailedtranslationofexperimentalischemicstroketreatments |