In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis

BackgroundA strong association between multiple sclerosis (MS) and Epstein-Barr virus (EBV) has been established but the exact role of EBV in MS remains controversial. Recently, molecular mimicry between EBNA1 and specific GlialCAM, CRYAB and ANO2 peptides has been suggested as a possible pathophysi...

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Main Authors: Nicole Vasilenko, Maria P. Tieck, Tanja Michel, Sonja Schembecker, Patricia Schwarz, Anna Guenther, Christoph Ruschil, Sven Poli, Ulf Ziemann, Antje Giede-Jeppe, Gisela Gabernet, Alex Dulovic, Markus C. Kowarik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis (MS)
Epstein-Barr virus (EBV)
EBV nuclear antigen type 1 (EBNA1)
anoctamin 2 (ANO2)
glial cell adhesion molecule (GlialCAM)
alpha B crystallin (CRYAB)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1487523/full
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