The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure
Background. The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma. Objective. To assess the impact of adherence and instillation technique on IOP control. Methods. A cross-sectional st...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/1683430 |
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| author | Tesfay Mehari Atey Workineh Shibeshi Abeba T. Giorgis Solomon Weldegebreal Asgedom |
| author_facet | Tesfay Mehari Atey Workineh Shibeshi Abeba T. Giorgis Solomon Weldegebreal Asgedom |
| author_sort | Tesfay Mehari Atey |
| collection | DOAJ |
| description | Background. The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma. Objective. To assess the impact of adherence and instillation technique on IOP control. Methods. A cross-sectional study was conducted on 359 glaucoma patients in Menelik II Hospital from June 1 to July 31, 2015. After conducting a Q-Q analysis, multiple binary logistic analyses, linear regression analyses, and two-tailed paired t-test were conducted to compare IOP in the baseline versus current measurements. Results. Intraocular pressure was controlled in 59.6% of the patients and was relatively well controlled during the study period (mean (M) = 17.911 mmHg, standard deviation (S) = 0.323) compared to the baseline (M=20.866 mmHg, S=0.383, t (358) = −6.70, p<0.0001). A unit increase in the administration technique score resulted in a 0.272 mmHg decrease in IOP (p=0.03). Moreover, primary angle-closure glaucoma (adjusted odds ratio (AOR) = 0.347, 95% confidence interval (CI): 0.144–0.836) and two medications (AOR = 1.869, 95% CI: 1.259–9.379) were factors affecting IOP. Conclusion. Good instillation technique of the medications was correlated with a reduction in IOP. Consequently, regular assessment of the instillation technique and IOP should be done for better management of the disease. |
| format | Article |
| id | doaj-art-bfaf4e7703ac44e8aae91a140f4ae747 |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-bfaf4e7703ac44e8aae91a140f4ae7472025-08-20T03:22:39ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/16834301683430The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular PressureTesfay Mehari Atey0Workineh Shibeshi1Abeba T. Giorgis2Solomon Weldegebreal Asgedom3Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, EthiopiaDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaDepartment of Ophthalmology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaClinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, EthiopiaBackground. The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma. Objective. To assess the impact of adherence and instillation technique on IOP control. Methods. A cross-sectional study was conducted on 359 glaucoma patients in Menelik II Hospital from June 1 to July 31, 2015. After conducting a Q-Q analysis, multiple binary logistic analyses, linear regression analyses, and two-tailed paired t-test were conducted to compare IOP in the baseline versus current measurements. Results. Intraocular pressure was controlled in 59.6% of the patients and was relatively well controlled during the study period (mean (M) = 17.911 mmHg, standard deviation (S) = 0.323) compared to the baseline (M=20.866 mmHg, S=0.383, t (358) = −6.70, p<0.0001). A unit increase in the administration technique score resulted in a 0.272 mmHg decrease in IOP (p=0.03). Moreover, primary angle-closure glaucoma (adjusted odds ratio (AOR) = 0.347, 95% confidence interval (CI): 0.144–0.836) and two medications (AOR = 1.869, 95% CI: 1.259–9.379) were factors affecting IOP. Conclusion. Good instillation technique of the medications was correlated with a reduction in IOP. Consequently, regular assessment of the instillation technique and IOP should be done for better management of the disease.http://dx.doi.org/10.1155/2017/1683430 |
| spellingShingle | Tesfay Mehari Atey Workineh Shibeshi Abeba T. Giorgis Solomon Weldegebreal Asgedom The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure Journal of Ophthalmology |
| title | The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure |
| title_full | The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure |
| title_fullStr | The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure |
| title_full_unstemmed | The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure |
| title_short | The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure |
| title_sort | impact of adherence and instillation proficiency of topical glaucoma medications on intraocular pressure |
| url | http://dx.doi.org/10.1155/2017/1683430 |
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