Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer?
ObjectivesWe evaluated the ability and accuracy of preoperative identification and localization of sentinel lymph nodes (SLNs) using intradermal injection of ultrasound contrast agent.Materials and methodsProspectively recruited 191 early breast cancer patients with clinically negative axillary lymp...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1471443/full |
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| author | Dayan Huang Dayan Huang Wenbin Cao Yunhao Luo Cheng Guan Yuyan Liu Yuyan Liu Chaonan Li Jie Chen Jing Luo Jun Luo |
| author_facet | Dayan Huang Dayan Huang Wenbin Cao Yunhao Luo Cheng Guan Yuyan Liu Yuyan Liu Chaonan Li Jie Chen Jing Luo Jun Luo |
| author_sort | Dayan Huang |
| collection | DOAJ |
| description | ObjectivesWe evaluated the ability and accuracy of preoperative identification and localization of sentinel lymph nodes (SLNs) using intradermal injection of ultrasound contrast agent.Materials and methodsProspectively recruited 191 early breast cancer patients with clinically negative axillary lymph nodes (ALNs). All participants received intradermal injection of microbubble contrast agent. Following the identification and localization of SLNs using contrast-enhanced ultrasound (CEUS), Markers were deployed in the SLNs US-guided. Subsequently, the SLNs with Markers were stained and marked with a suspension of nano-carbon US-guided to assist in intraoperative localization of SLNs. Standard SLNB with methylene blue tracing was performed intraoperatively to assess the consistency between the two methods of SLNs localization, thereby determining the ability and accuracy of CEUS in identifying and localizing SLNs.ResultsA total of 179 patients were included in the final evaluation analysis, in which a microbubble contrast agent was injected subcutaneously in the areolar region. A total of 201 SLNs were identified, with a median of 1 SLN per patient. Each SLN was identified in 157 patients, and two SLNs were identified in 22 patients. Among the 201 SLNs from the 179 patients, the proportion that could be individually matched between CEUS and the blue dye method was 95.5% (192/201), and the consistency evaluation in SLNs identification between CEUS and blue dye staining was excellent (Kappa value = 0.62, P < 0.001).ConclusionThe consistency of identification and localization of SLNs in early breast cancer patients between CEUS and the blue dye method was strong. |
| format | Article |
| id | doaj-art-bfad944d2c3947e193bee854b7314d57 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bfad944d2c3947e193bee854b7314d572025-08-20T02:33:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14714431471443Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer?Dayan Huang0Dayan Huang1Wenbin Cao2Yunhao Luo3Cheng Guan4Yuyan Liu5Yuyan Liu6Chaonan Li7Jie Chen8Jing Luo9Jun Luo10School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaObjectivesWe evaluated the ability and accuracy of preoperative identification and localization of sentinel lymph nodes (SLNs) using intradermal injection of ultrasound contrast agent.Materials and methodsProspectively recruited 191 early breast cancer patients with clinically negative axillary lymph nodes (ALNs). All participants received intradermal injection of microbubble contrast agent. Following the identification and localization of SLNs using contrast-enhanced ultrasound (CEUS), Markers were deployed in the SLNs US-guided. Subsequently, the SLNs with Markers were stained and marked with a suspension of nano-carbon US-guided to assist in intraoperative localization of SLNs. Standard SLNB with methylene blue tracing was performed intraoperatively to assess the consistency between the two methods of SLNs localization, thereby determining the ability and accuracy of CEUS in identifying and localizing SLNs.ResultsA total of 179 patients were included in the final evaluation analysis, in which a microbubble contrast agent was injected subcutaneously in the areolar region. A total of 201 SLNs were identified, with a median of 1 SLN per patient. Each SLN was identified in 157 patients, and two SLNs were identified in 22 patients. Among the 201 SLNs from the 179 patients, the proportion that could be individually matched between CEUS and the blue dye method was 95.5% (192/201), and the consistency evaluation in SLNs identification between CEUS and blue dye staining was excellent (Kappa value = 0.62, P < 0.001).ConclusionThe consistency of identification and localization of SLNs in early breast cancer patients between CEUS and the blue dye method was strong.https://www.frontiersin.org/articles/10.3389/fonc.2024.1471443/fullbreast cancercontrast-enhanced ultrasoundsentinel lymph nodemarkernanocarbon |
| spellingShingle | Dayan Huang Dayan Huang Wenbin Cao Yunhao Luo Cheng Guan Yuyan Liu Yuyan Liu Chaonan Li Jie Chen Jing Luo Jun Luo Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? Frontiers in Oncology breast cancer contrast-enhanced ultrasound sentinel lymph node marker nanocarbon |
| title | Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? |
| title_full | Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? |
| title_fullStr | Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? |
| title_full_unstemmed | Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? |
| title_short | Can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer? |
| title_sort | can preoperative percutaneous injection of ultrasound contrast agent locate sentinel lymph nodes of breast cancer |
| topic | breast cancer contrast-enhanced ultrasound sentinel lymph node marker nanocarbon |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1471443/full |
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