Non-alcoholic fatty liver disease in obese persons with diabetes
Background. Obesity, diabetes and different lipid metabolic disorders are the most frequent risk factors for nonalcoholic fatty liver disease, presented with a high variability in clinical and histological findings. Case report. We presented a case of 37-year-old male, suffering from type 2 diabetes...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2007-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500708569T.pdf |
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| author | Tomašević Ratko Golubović Gradimir Stanković Dragana Gluvić Zoran Dugalić Predrag Pavlović Aleksandar |
| author_facet | Tomašević Ratko Golubović Gradimir Stanković Dragana Gluvić Zoran Dugalić Predrag Pavlović Aleksandar |
| author_sort | Tomašević Ratko |
| collection | DOAJ |
| description | Background. Obesity, diabetes and different lipid metabolic disorders are the most frequent risk factors for nonalcoholic fatty liver disease, presented with a high variability in clinical and histological findings. Case report. We presented a case of 37-year-old male, suffering from type 2 diabetes mellitus, grade III obesity (BMI 45 kg/m2) and multiple metabolic disorders. Abdominal ultrasound revealed hepatomegaly during the last six months. Laboratory diagnostics showed increased serum transaminase levels. Serologic markers for viral hepatitis B and C were negative. The patient denied significant alcohol consumption. Liver biopsy and pathohistologic finding revealed macro- (III grade) and microvesicular (I grade) fatty degeneration, as well as mixed-cell portal infiltration with moderate liver fibrosis, corresponding to the typical presentation of NASH (Non Alcoholic Steatohepatitis). Conclusion. NASH treatment options include the reduction of body mass and an adequate antidiabetic and dislipidemia treatment. The aim of all therapeutic measures was to stop the progression of the disease, to prevent the progression of fibrosis and the development of of cirrhosis. . |
| format | Article |
| id | doaj-art-bfa766c337694a069a35b1e2e436a49d |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-bfa766c337694a069a35b1e2e436a49d2025-08-20T02:02:26ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502007-01-0164856957210.2298/VSP0708569TNon-alcoholic fatty liver disease in obese persons with diabetesTomašević RatkoGolubović GradimirStanković DraganaGluvić ZoranDugalić PredragPavlović AleksandarBackground. Obesity, diabetes and different lipid metabolic disorders are the most frequent risk factors for nonalcoholic fatty liver disease, presented with a high variability in clinical and histological findings. Case report. We presented a case of 37-year-old male, suffering from type 2 diabetes mellitus, grade III obesity (BMI 45 kg/m2) and multiple metabolic disorders. Abdominal ultrasound revealed hepatomegaly during the last six months. Laboratory diagnostics showed increased serum transaminase levels. Serologic markers for viral hepatitis B and C were negative. The patient denied significant alcohol consumption. Liver biopsy and pathohistologic finding revealed macro- (III grade) and microvesicular (I grade) fatty degeneration, as well as mixed-cell portal infiltration with moderate liver fibrosis, corresponding to the typical presentation of NASH (Non Alcoholic Steatohepatitis). Conclusion. NASH treatment options include the reduction of body mass and an adequate antidiabetic and dislipidemia treatment. The aim of all therapeutic measures was to stop the progression of the disease, to prevent the progression of fibrosis and the development of of cirrhosis. .http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500708569T.pdfobesitydiabetes mellitus, type 2dyslipidemiasfattyliverdiagnosis, therapytreatment outcome |
| spellingShingle | Tomašević Ratko Golubović Gradimir Stanković Dragana Gluvić Zoran Dugalić Predrag Pavlović Aleksandar Non-alcoholic fatty liver disease in obese persons with diabetes Vojnosanitetski Pregled obesity diabetes mellitus, type 2 dyslipidemias fattyliver diagnosis, therapy treatment outcome |
| title | Non-alcoholic fatty liver disease in obese persons with diabetes |
| title_full | Non-alcoholic fatty liver disease in obese persons with diabetes |
| title_fullStr | Non-alcoholic fatty liver disease in obese persons with diabetes |
| title_full_unstemmed | Non-alcoholic fatty liver disease in obese persons with diabetes |
| title_short | Non-alcoholic fatty liver disease in obese persons with diabetes |
| title_sort | non alcoholic fatty liver disease in obese persons with diabetes |
| topic | obesity diabetes mellitus, type 2 dyslipidemias fattyliver diagnosis, therapy treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500708569T.pdf |
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