WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

Abstract Signaling from the T cell antigen receptor (TCR) on CD4+ T cells plays a critical role in adaptive immune responses by inducing T cell activation, proliferation, and differentiation. Here we demonstrate that WNK1, a kinase implicated in osmoregulation in the kidney, is required in T cells t...

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Bibliographic Details
Main Authors: Joshua Biggs O’May, Lesley Vanes, Leonard L. de Boer, David A. Lewis, Harald Hartweger, Simone Kunzelmann, Darryl Hayward, Miriam Llorian, Robert Köchl, Victor L. J. Tybulewicz
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56778-x
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