Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention
This in vitro study evaluated the protective effect of an Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of the demineralized lesions in dentin after cariogenic pH cycling. Methods: Sixty bovine dentin blocks (4 × 4 × 2 mm) were randomly assigned int...
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MDPI AG
2024-12-01
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| author | Andressa Feitosa Bezerra de Oliveira Bianne Maria de Melo Costa Anderson Gomes Forte Elizabeth Barreto Galvão de Sousa Vitória Régia Rolim Nunes Arthur Felipe de Brito Andrade Juliellen Luiz da Cunha Nayanna Lana Soares Fernandes Ana Maria Barros Chaves Pereira Fabiano Vieira Vilhena Paulo Henrique Perlatti D’Alpino Fábio Correia Sampaio |
| author_facet | Andressa Feitosa Bezerra de Oliveira Bianne Maria de Melo Costa Anderson Gomes Forte Elizabeth Barreto Galvão de Sousa Vitória Régia Rolim Nunes Arthur Felipe de Brito Andrade Juliellen Luiz da Cunha Nayanna Lana Soares Fernandes Ana Maria Barros Chaves Pereira Fabiano Vieira Vilhena Paulo Henrique Perlatti D’Alpino Fábio Correia Sampaio |
| author_sort | Andressa Feitosa Bezerra de Oliveira |
| collection | DOAJ |
| description | This in vitro study evaluated the protective effect of an Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of the demineralized lesions in dentin after cariogenic pH cycling. Methods: Sixty bovine dentin blocks (4 × 4 × 2 mm) were randomly assigned into five groups (n = twelve/group): RGS<sub>1</sub> (Si toothpaste with 1450 ppm F), RGS<sub>2</sub> (Si toothpaste with 1100 ppm F), RGS<sub>3</sub> (fluoride-free Si toothpaste), negative control (NC) (fluoride-free toothpaste), and positive control (PC) (1450 ppm F toothpaste). The specimens underwent a three-day pH cycling model simulating the oral environment with twice-daily brushing. The mineral loss (ΔF) and lesion depth (ΔF<sub>max</sub>) were assessed using quantitative light-induced fluorescence (QLF), and scanning electron microscopy (SEM) provided a morphological analysis. Elemental analyses were performed with an energy-dispersive X-ray spectrometer (EDS). ANOVA and Tukey’s test were used for the data analysis (α = 5%). Results: EDS confirmed the Si in the toothpaste formulations. The groups treated with fluoride silicon toothpastes (RGS<sub>1</sub>, RGS<sub>2</sub>) had significantly reduced mineral loss and lesion depth compared to the PC group. The NC group exhibited the greatest mineral loss and lesion depth. SEM images revealed occluded superficial dentin tubules and a protective mineral layer in the groups treated with Si toothpaste, whereas no deposition (NC group) or limited mineral deposition (PC group) was observed in the control groups. Conclusions: The findings suggest that the Si toothpastes favored protection against dentin demineralization, even at a lower concentration or free of fluoride, with dentin tubule occlusion, thus representing a promising oral care product over traditional fluoride toothpastes. |
| format | Article |
| id | doaj-art-bfa6793c3cd04f358e883088bc948e65 |
| institution | DOAJ |
| issn | 2673-6373 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Oral |
| spelling | doaj-art-bfa6793c3cd04f358e883088bc948e652025-08-20T02:50:41ZengMDPI AGOral2673-63732024-12-014457858810.3390/oral4040045Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries PreventionAndressa Feitosa Bezerra de Oliveira0Bianne Maria de Melo Costa1Anderson Gomes Forte2Elizabeth Barreto Galvão de Sousa3Vitória Régia Rolim Nunes4Arthur Felipe de Brito Andrade5Juliellen Luiz da Cunha6Nayanna Lana Soares Fernandes7Ana Maria Barros Chaves Pereira8Fabiano Vieira Vilhena9Paulo Henrique Perlatti D’Alpino10Fábio Correia Sampaio11Department of Morphology, Health Science Center, Federal University of Paraíba, João Pessoa 58051-900, BrazilPostgraduate Dentistry Program, Federal University of Paraíba, João Pessoa 58051-900, BrazilDental School, Institutional Scientific Initiation Scholarship Program, Federal University of Paraiba, João Pessoa 58051-900, BrazilPostgraduate Dentistry Program, Federal University of Paraíba, João Pessoa 58051-900, BrazilDental School, Institutional Scientific Initiation Scholarship Program, Federal University of Paraiba, João Pessoa 58051-900, BrazilDental School, Institutional Scientific Initiation Scholarship Program, Federal University of Paraiba, João Pessoa 58051-900, BrazilPostgraduate Dentistry Program, Federal University of Paraíba, João Pessoa 58051-900, BrazilPostgraduate Dentistry Program, Federal University of Paraíba, João Pessoa 58051-900, BrazilDepartment of Morphology, Health Science Center, Federal University of Paraíba, João Pessoa 58051-900, BrazilTrials Pesquisa e Desenvolvimento, São Paulo 01236-030, BrazilSchool of Sciences, São Paulo State University (UNESP), São Paulo 17033-360, BrazilDepartment of Clinical and Community Dentistry, Health Science Center, Federal University of Paraíba, João Pessoa 58051-900, BrazilThis in vitro study evaluated the protective effect of an Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of the demineralized lesions in dentin after cariogenic pH cycling. Methods: Sixty bovine dentin blocks (4 × 4 × 2 mm) were randomly assigned into five groups (n = twelve/group): RGS<sub>1</sub> (Si toothpaste with 1450 ppm F), RGS<sub>2</sub> (Si toothpaste with 1100 ppm F), RGS<sub>3</sub> (fluoride-free Si toothpaste), negative control (NC) (fluoride-free toothpaste), and positive control (PC) (1450 ppm F toothpaste). The specimens underwent a three-day pH cycling model simulating the oral environment with twice-daily brushing. The mineral loss (ΔF) and lesion depth (ΔF<sub>max</sub>) were assessed using quantitative light-induced fluorescence (QLF), and scanning electron microscopy (SEM) provided a morphological analysis. Elemental analyses were performed with an energy-dispersive X-ray spectrometer (EDS). ANOVA and Tukey’s test were used for the data analysis (α = 5%). Results: EDS confirmed the Si in the toothpaste formulations. The groups treated with fluoride silicon toothpastes (RGS<sub>1</sub>, RGS<sub>2</sub>) had significantly reduced mineral loss and lesion depth compared to the PC group. The NC group exhibited the greatest mineral loss and lesion depth. SEM images revealed occluded superficial dentin tubules and a protective mineral layer in the groups treated with Si toothpaste, whereas no deposition (NC group) or limited mineral deposition (PC group) was observed in the control groups. Conclusions: The findings suggest that the Si toothpastes favored protection against dentin demineralization, even at a lower concentration or free of fluoride, with dentin tubule occlusion, thus representing a promising oral care product over traditional fluoride toothpastes.https://www.mdpi.com/2673-6373/4/4/45dental cariesbiomimeticsfluoridesiliconremineralizationdentin |
| spellingShingle | Andressa Feitosa Bezerra de Oliveira Bianne Maria de Melo Costa Anderson Gomes Forte Elizabeth Barreto Galvão de Sousa Vitória Régia Rolim Nunes Arthur Felipe de Brito Andrade Juliellen Luiz da Cunha Nayanna Lana Soares Fernandes Ana Maria Barros Chaves Pereira Fabiano Vieira Vilhena Paulo Henrique Perlatti D’Alpino Fábio Correia Sampaio Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention Oral dental caries biomimetics fluoride silicon remineralization dentin |
| title | Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention |
| title_full | Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention |
| title_fullStr | Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention |
| title_full_unstemmed | Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention |
| title_short | Beyond Fluoride: Exploring Silicon’s Potential for Dental Repair and Caries Prevention |
| title_sort | beyond fluoride exploring silicon s potential for dental repair and caries prevention |
| topic | dental caries biomimetics fluoride silicon remineralization dentin |
| url | https://www.mdpi.com/2673-6373/4/4/45 |
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