The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis
Background: Acute ischemic stroke (AIS) remains a leading cause of disability worldwide, placing a significant burden on patients’ quality of life and healthcare systems. Pentraxin-3 (PTX-3), an inflammatory biomarker, may be associated with AIS prognosis; however, existing evidence is inconclusive....
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-05-01
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| Series: | Balkan Medical Journal |
| Online Access: | https://balkanmedicaljournal.org/text.php?lang=en&id=2711 |
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| author | Yanrong Zhu Kui Fan Xujuan Zhao Kaiwen Hou |
| author_facet | Yanrong Zhu Kui Fan Xujuan Zhao Kaiwen Hou |
| author_sort | Yanrong Zhu |
| collection | DOAJ |
| description | Background: Acute ischemic stroke (AIS) remains a leading cause of disability worldwide, placing a significant burden on patients’ quality of life and healthcare systems. Pentraxin-3 (PTX-3), an inflammatory biomarker, may be associated with AIS prognosis; however, existing evidence is inconclusive.
Aims: To examine whether serum PTX-3 levels at admission are linked to the likelihood of poor functional outcomes in AIS patients.
Study Design: Systematic review and meta-analysis.
Methods: A comprehensive search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases was conducted to identify studies evaluating PTX-3 levels in AIS patients. Eligible studies included those that measured PTX-3 within 48 h of admission and evaluated outcomes using the modified Rankin Scale, with scores > 2 defined as poor outcomes. A random-effects model was used to calculate pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs).
Results: Ten cohort studies involving1202 AIS patients were included. Higher PTX-3 levels at admission were significantly associated with an increased risk of poor functional outcomes (OR, 2.06; 95% CI, 1.72-2.47; p < 0.001), with no significant heterogeneity (I² = 0%). Meta-regression showed that using higher PTX-3 cutoff values reported stronger associations (p < 0.05). Subgroup analyses confirmed consistent associations across study designs, patient characteristics, and timing of outcome assessment. The association was more pronounced in studies using a PTX-3 cutoff ≥ 3.3 ng/mL compared to those with a cutoff < 3.3 ng/mL.
Conclusion: Elevated serum PTX-3 levels at admission may serve as a prognostic biomarker for poor functional outcomes in AIS. Differences in PTX-3 cutoff values and potential residual confounding should also be considered. Further multicenter studies involving diverse populations are necessary to confirm these results and establish PTX-3 as a reliable prognostic indicator in clinical practice. |
| format | Article |
| id | doaj-art-bfa1aaecf7f042b9b5e1f67f12d83e98 |
| institution | Kabale University |
| issn | 2146-3123 2146-3131 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj-art-bfa1aaecf7f042b9b5e1f67f12d83e982025-08-20T03:53:02ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312025-05-0142320121110.4274/balkanmedj.galenos.2025.2025-1-36The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-AnalysisYanrong Zhu0https://orcid.org/0009-0006-4062-8101Kui Fan1https://orcid.org/0009-0000-2564-4417Xujuan Zhao2https://orcid.org/0009-0009-5405-7049Kaiwen Hou3https://orcid.org/0009-0008-2975-9412Clinic of Physical Examination Center of the Outpatient, General Hospital of the Western Theater Command of the People’s Liberation Army of China, Chengdu, ChinaClinic of Physical Examination Center of the Outpatient, General Hospital of the Western Theater Command of the People’s Liberation Army of China, Chengdu, ChinaClinic of Physical Examination Center of the Outpatient, General Hospital of the Western Theater Command of the People’s Liberation Army of China, Chengdu, ChinaClinic of Physical Examination Center of the Outpatient, General Hospital of the Western Theater Command of the People’s Liberation Army of China, Chengdu, ChinaBackground: Acute ischemic stroke (AIS) remains a leading cause of disability worldwide, placing a significant burden on patients’ quality of life and healthcare systems. Pentraxin-3 (PTX-3), an inflammatory biomarker, may be associated with AIS prognosis; however, existing evidence is inconclusive. Aims: To examine whether serum PTX-3 levels at admission are linked to the likelihood of poor functional outcomes in AIS patients. Study Design: Systematic review and meta-analysis. Methods: A comprehensive search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases was conducted to identify studies evaluating PTX-3 levels in AIS patients. Eligible studies included those that measured PTX-3 within 48 h of admission and evaluated outcomes using the modified Rankin Scale, with scores > 2 defined as poor outcomes. A random-effects model was used to calculate pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: Ten cohort studies involving1202 AIS patients were included. Higher PTX-3 levels at admission were significantly associated with an increased risk of poor functional outcomes (OR, 2.06; 95% CI, 1.72-2.47; p < 0.001), with no significant heterogeneity (I² = 0%). Meta-regression showed that using higher PTX-3 cutoff values reported stronger associations (p < 0.05). Subgroup analyses confirmed consistent associations across study designs, patient characteristics, and timing of outcome assessment. The association was more pronounced in studies using a PTX-3 cutoff ≥ 3.3 ng/mL compared to those with a cutoff < 3.3 ng/mL. Conclusion: Elevated serum PTX-3 levels at admission may serve as a prognostic biomarker for poor functional outcomes in AIS. Differences in PTX-3 cutoff values and potential residual confounding should also be considered. Further multicenter studies involving diverse populations are necessary to confirm these results and establish PTX-3 as a reliable prognostic indicator in clinical practice.https://balkanmedicaljournal.org/text.php?lang=en&id=2711 |
| spellingShingle | Yanrong Zhu Kui Fan Xujuan Zhao Kaiwen Hou The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis Balkan Medical Journal |
| title | The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis |
| title_full | The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis |
| title_fullStr | The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis |
| title_full_unstemmed | The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis |
| title_short | The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis |
| title_sort | association between serum pentraxin 3 level at admission and the functional outcome of patients after acute ischemic stroke a meta analysis |
| url | https://balkanmedicaljournal.org/text.php?lang=en&id=2711 |
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