Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/184154 |
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| _version_ | 1832560551710949376 |
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| author | Androniki Kretsovali Christiana Hadjimichael Nikolaos Charmpilas |
| author_facet | Androniki Kretsovali Christiana Hadjimichael Nikolaos Charmpilas |
| author_sort | Androniki Kretsovali |
| collection | DOAJ |
| description | Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies. |
| format | Article |
| id | doaj-art-bf9d4a6ec7144cf48c93f217efb5b35e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-bf9d4a6ec7144cf48c93f217efb5b35e2025-02-03T01:27:18ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/184154184154Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and ReprogrammingAndroniki Kretsovali0Christiana Hadjimichael1Nikolaos Charmpilas2Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, 70013 Crete, GreeceInstitute of Molecular Biology and Biotechnology, FORTH, Heraklion, 70013 Crete, GreeceDepartment of Biology, University of Crete, Heraklion, 71409 Crete, GreeceHistone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies.http://dx.doi.org/10.1155/2012/184154 |
| spellingShingle | Androniki Kretsovali Christiana Hadjimichael Nikolaos Charmpilas Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming Stem Cells International |
| title | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
| title_full | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
| title_fullStr | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
| title_full_unstemmed | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
| title_short | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
| title_sort | histone deacetylase inhibitors in cell pluripotency differentiation and reprogramming |
| url | http://dx.doi.org/10.1155/2012/184154 |
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