Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background
We report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as typ...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1590544/full |
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| author | Shiyu Peng Shuxin Tian |
| author_facet | Shiyu Peng Shuxin Tian |
| author_sort | Shiyu Peng |
| collection | DOAJ |
| description | We report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as type O-IIa+IIc, located on the posterior wall of the upper gastric body. Endoscopic biopsy indicated high-grade intraepithelial neoplasia, which promoted endoscopic submucosal dissection (ESD). Pathological examination confirmed mucosal adenocarcinoma with submucosal ectopic gastric glands. Given the association of such lesions with gastric cancer, careful diagnosis and treatment are essential. The patient remained disease-free without recurrence during a 2-year follow-up period. |
| format | Article |
| id | doaj-art-bf9d1a9117a24c018e61e4e40a37d3d7 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bf9d1a9117a24c018e61e4e40a37d3d72025-08-20T03:24:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15905441590544Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative backgroundShiyu PengShuxin TianWe report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as type O-IIa+IIc, located on the posterior wall of the upper gastric body. Endoscopic biopsy indicated high-grade intraepithelial neoplasia, which promoted endoscopic submucosal dissection (ESD). Pathological examination confirmed mucosal adenocarcinoma with submucosal ectopic gastric glands. Given the association of such lesions with gastric cancer, careful diagnosis and treatment are essential. The patient remained disease-free without recurrence during a 2-year follow-up period.https://www.frontiersin.org/articles/10.3389/fonc.2025.1590544/fullsubmucosal ectopic gastric glandsearly gastric cancercase reporta 55-year-old femalepathological examination |
| spellingShingle | Shiyu Peng Shuxin Tian Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background Frontiers in Oncology submucosal ectopic gastric glands early gastric cancer case report a 55-year-old female pathological examination |
| title | Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background |
| title_full | Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background |
| title_fullStr | Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background |
| title_full_unstemmed | Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background |
| title_short | Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background |
| title_sort | case report and literature analysis of ectopic gastric glands combined with intestinal type gastric cancer in an hp negative background |
| topic | submucosal ectopic gastric glands early gastric cancer case report a 55-year-old female pathological examination |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1590544/full |
| work_keys_str_mv | AT shiyupeng casereportandliteratureanalysisofectopicgastricglandscombinedwithintestinaltypegastriccancerinanhpnegativebackground AT shuxintian casereportandliteratureanalysisofectopicgastricglandscombinedwithintestinaltypegastriccancerinanhpnegativebackground |