Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
Abstract Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular death characterized by lipid peroxidation, is involved in the pathogenesis of diabetic cardiovascular diseases. The susc...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02614-x |
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| _version_ | 1823863300101767168 |
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| author | Ziyi Wang Chao Wu Dong Yin Kefei Dou |
| author_facet | Ziyi Wang Chao Wu Dong Yin Kefei Dou |
| author_sort | Ziyi Wang |
| collection | DOAJ |
| description | Abstract Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular death characterized by lipid peroxidation, is involved in the pathogenesis of diabetic cardiovascular diseases. The susceptibility to ferroptosis in diabetic hearts is possibly related to myocardial iron accumulation, abnormal lipid metabolism and excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests ferroptosis can be the therapeutic target for diabetic cardiovascular diseases. This review summarizes ferroptosis-related mechanisms in the pathogenesis of diabetic cardiovascular diseases and novel therapeutic choices targeting ferroptosis-related pathways. Further study on ferroptosis-mediated cardiac injury can enhance our understanding of the pathophysiology of diabetic cardiovascular diseases and provide more potential therapeutic choices. |
| format | Article |
| id | doaj-art-bf9c289ec11d4de89e38b844a2705068 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-bf9c289ec11d4de89e38b844a27050682025-02-09T12:10:51ZengBMCCardiovascular Diabetology1475-28402025-02-0124111610.1186/s12933-025-02614-xFerroptosis: mechanism and role in diabetes-related cardiovascular diseasesZiyi Wang0Chao Wu1Dong Yin2Kefei Dou3Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular death characterized by lipid peroxidation, is involved in the pathogenesis of diabetic cardiovascular diseases. The susceptibility to ferroptosis in diabetic hearts is possibly related to myocardial iron accumulation, abnormal lipid metabolism and excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests ferroptosis can be the therapeutic target for diabetic cardiovascular diseases. This review summarizes ferroptosis-related mechanisms in the pathogenesis of diabetic cardiovascular diseases and novel therapeutic choices targeting ferroptosis-related pathways. Further study on ferroptosis-mediated cardiac injury can enhance our understanding of the pathophysiology of diabetic cardiovascular diseases and provide more potential therapeutic choices.https://doi.org/10.1186/s12933-025-02614-xFerroptosisDiabetesCardiovascular diseasesMechanismTherapeutic targets |
| spellingShingle | Ziyi Wang Chao Wu Dong Yin Kefei Dou Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases Cardiovascular Diabetology Ferroptosis Diabetes Cardiovascular diseases Mechanism Therapeutic targets |
| title | Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases |
| title_full | Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases |
| title_fullStr | Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases |
| title_full_unstemmed | Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases |
| title_short | Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases |
| title_sort | ferroptosis mechanism and role in diabetes related cardiovascular diseases |
| topic | Ferroptosis Diabetes Cardiovascular diseases Mechanism Therapeutic targets |
| url | https://doi.org/10.1186/s12933-025-02614-x |
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