Control of T-cell immunity by fatty acid metabolism
Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence of fatty acids on T-cell subsets, including CD8+ T cells, TH1, TH17, Treg (regulatory T cells), and TFH (T follicular helper) cel...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2024-12-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
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| Online Access: | http://e-apem.org/upload/pdf/apem-2448160-080.pdf |
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| _version_ | 1849311265546043392 |
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| author | Jaemin Kim Yoosun Lee Yeonseok Chung |
| author_facet | Jaemin Kim Yoosun Lee Yeonseok Chung |
| author_sort | Jaemin Kim |
| collection | DOAJ |
| description | Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence of fatty acids on T-cell subsets, including CD8+ T cells, TH1, TH17, Treg (regulatory T cells), and TFH (T follicular helper) cells. Fatty acids impact T cells by modulating signaling pathways, inducing metabolic changes, altering cellular structures, and regulating gene expression epigenetically. These processes affect T-cell activation, differentiation, and function, with implications for diseases such as autoimmune disease and cancer. Based on these insights, fatty acid pathways can potentially be modulated by novel therapeutics, paving the way for novel treatment approaches for immune-mediated disorders and cancer immunotherapy. |
| format | Article |
| id | doaj-art-bf9988b1332f4fd2b0bffe06202aec6c |
| institution | Kabale University |
| issn | 2287-1012 2287-1292 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj-art-bf9988b1332f4fd2b0bffe06202aec6c2025-08-20T03:53:27ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922024-12-0129635636410.6065/apem.2448160.0801064Control of T-cell immunity by fatty acid metabolismJaemin Kim0Yoosun Lee1Yeonseok Chung2 Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, KoreaFatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence of fatty acids on T-cell subsets, including CD8+ T cells, TH1, TH17, Treg (regulatory T cells), and TFH (T follicular helper) cells. Fatty acids impact T cells by modulating signaling pathways, inducing metabolic changes, altering cellular structures, and regulating gene expression epigenetically. These processes affect T-cell activation, differentiation, and function, with implications for diseases such as autoimmune disease and cancer. Based on these insights, fatty acid pathways can potentially be modulated by novel therapeutics, paving the way for novel treatment approaches for immune-mediated disorders and cancer immunotherapy.http://e-apem.org/upload/pdf/apem-2448160-080.pdffatty acidsfatty acid metabolismfatty acid signalingimmunometabolismt-cell differentiation |
| spellingShingle | Jaemin Kim Yoosun Lee Yeonseok Chung Control of T-cell immunity by fatty acid metabolism Annals of Pediatric Endocrinology & Metabolism fatty acids fatty acid metabolism fatty acid signaling immunometabolism t-cell differentiation |
| title | Control of T-cell immunity by fatty acid metabolism |
| title_full | Control of T-cell immunity by fatty acid metabolism |
| title_fullStr | Control of T-cell immunity by fatty acid metabolism |
| title_full_unstemmed | Control of T-cell immunity by fatty acid metabolism |
| title_short | Control of T-cell immunity by fatty acid metabolism |
| title_sort | control of t cell immunity by fatty acid metabolism |
| topic | fatty acids fatty acid metabolism fatty acid signaling immunometabolism t-cell differentiation |
| url | http://e-apem.org/upload/pdf/apem-2448160-080.pdf |
| work_keys_str_mv | AT jaeminkim controloftcellimmunitybyfattyacidmetabolism AT yoosunlee controloftcellimmunitybyfattyacidmetabolism AT yeonseokchung controloftcellimmunitybyfattyacidmetabolism |